methyl N-(4-(6-((1S)-1-((tert-butoxycarbonyl)amino)but-3-en-1-yl)-2-oxo-1,2-dihydropyridin-4-yl)-3-(pent-4-enoylamino)phenyl)carbamate

Base Information

Chemical Name:methyl N-(4-(6-((1S)-1-((tert-butoxycarbonyl)amino)but-3-en-1-yl)-2-oxo-1,2-dihydropyridin-4-yl)-3-(pent-4-enoylamino)phenyl)carbamate
CAS No.:1422387-39-0
Molecular Formula:C₂₇H₃₄N₄O₆
Molecular Weight:510.59
Hs Code.:

Synonyms:methyl N-(4-(6-((1S)-1-((tert-butoxycarbonyl)amino)but-3-en-1-yl)-2-oxo-1,2-dihydropyridin-4-yl)-3-(pent-4-enoylamino)phenyl)carbamate

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Chemical Property of methyl N-(4-(6-((1S)-1-((tert-butoxycarbonyl)amino)but-3-en-1-yl)-2-oxo-1,2-dihydropyridin-4-yl)-3-(pent-4-enoylamino)phenyl)carbamate

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Technology Process of methyl N-(4-(6-((1S)-1-((tert-butoxycarbonyl)amino)but-3-en-1-yl)-2-oxo-1,2-dihydropyridin-4-yl)-3-(pent-4-enoylamino)phenyl)carbamate

There total 11 articles about methyl N-(4-(6-((1S)-1-((tert-butoxycarbonyl)amino)but-3-en-1-yl)-2-oxo-1,2-dihydropyridin-4-yl)-3-(pent-4-enoylamino)phenyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 39716-58-0
pent-4-enoyl chloride

: 1422388-52-0
methyl N-(3-amino-4-(6-((1S)-1-((tert-butoxycarbonyl)amino)but-3-en-1-yl)-2-oxo-1,2-dihydropyridin-4-yl)phenyl)carbamate

: 1422387-39-0
methyl N-(4-(6-((1S)-1-((tert-butoxycarbonyl)amino)but-3-en-1-yl)-2-oxo-1,2-dihydropyridin-4-yl)-3-(pent-4-enoylamino)phenyl)carbamate

Guidance literature:: pent-4-enoyl chloride; methyl N-(3-amino-4-(6-((1S)-1-((tert-butoxycarbonyl)amino)but-3-en-1-yl)-2-oxo-1,2-dihydropyridin-4-yl)phenyl)carbamate; With pyridine; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

With sodium hydroxide; In tetrahydrofuran; at 30 ℃; for 1.5h;

Reference yield:

: 1422387-32-3
4-(1,3-dioxolan-2-yl)-3-nitrobenzoic acid

: 1422387-39-0
methyl N-(4-(6-((1S)-1-((tert-butoxycarbonyl)amino)but-3-en-1-yl)-2-oxo-1,2-dihydropyridin-4-yl)-3-(pent-4-enoylamino)phenyl)carbamate

Guidance literature:: Multi-step reaction with 7 steps

1.1: chloroformic acid ethyl ester; triethylamine / tetrahydrofuran / 0.67 h / -5 °C

2.1: toluene / 1 h / 110 °C

2.2: 80 °C

3.1: water; trifluoroacetic acid / 3 h / 20 °C

4.1: potassium carbonate / tetrahydrofuran; ethanol / 0 - 55 °C / Inert atmosphere

5.1: ammonium acetate / ethanol / 75 °C

6.1: zinc; ammonium chloride / methanol / 20 - 65 °C

7.1: pyridine / dichloromethane / 0 - 20 °C / Inert atmosphere

7.2: 1.5 h / 30 °C

With pyridine; ammonium acetate; water; chloroformic acid ethyl ester; potassium carbonate; ammonium chloride; triethylamine; trifluoroacetic acid; zinc; In tetrahydrofuran; methanol; ethanol; dichloromethane; toluene;

Reference yield:

: 89985-87-5
methyl (2S)-2-tert-butoxycarbonylamino-4-pentenoate

: 1422387-39-0
methyl N-(4-(6-((1S)-1-((tert-butoxycarbonyl)amino)but-3-en-1-yl)-2-oxo-1,2-dihydropyridin-4-yl)-3-(pent-4-enoylamino)phenyl)carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-butyllithium / tetrahydrofuran / -78 °C

1.2: -78 °C

2.1: potassium carbonate / tetrahydrofuran; ethanol / 0 - 55 °C / Inert atmosphere

3.1: ammonium acetate / ethanol / 75 °C

4.1: zinc; ammonium chloride / methanol / 20 - 65 °C

5.1: pyridine / dichloromethane / 0 - 20 °C / Inert atmosphere

5.2: 1.5 h / 30 °C

With pyridine; n-butyllithium; ammonium acetate; potassium carbonate; ammonium chloride; zinc; In tetrahydrofuran; methanol; ethanol; dichloromethane;