3-benzylidene-2-[3-(dimethylamino)propyl]-2,3-dihydro-1H-isoindol-1-one

Base Information

• Chemical Name: 3-benzylidene-2-[3-(dimethylamino)propyl]-2,3-dihydro-1H-isoindol-1-one
• CAS No.: 284685-12-7
• Molecular Formula: C₂₀H₂₂N₂O
• Molecular Weight: 306.407
• Mol file: 284685-12-7.mol

Synonyms:3-benzylidene-2-[3-(dimethylamino)propyl]-2,3-dihydro-1H-isoindol-1-one

Chemical Property of 3-benzylidene-2-[3-(dimethylamino)propyl]-2,3-dihydro-1H-isoindol-1-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-benzylidene-2-[3-(dimethylamino)propyl]-2,3-dihydro-1H-isoindol-1-one

There total 5 articles about 3-benzylidene-2-[3-(dimethylamino)propyl]-2,3-dihydro-1H-isoindol-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

phthalic anhydride (85-44-9) → 3-benzylidene-2-[3-(dimethylamino)propyl]-2,3-dihydro-1H-isoindol-1-one (284685-12-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 70 percent / AcONa / 4 h / 250 - 300 °C

2: ethanol / 4 h / Heating

3: formic acid / 0.5 h / 130 - 140 °C

With formic acid; sodium acetate; In ethanol; 1: Condensation / 2: Addition / 3: Elimination;

DOI:10.1021/jm991136e

Reference yield:

3-benzylidene-2-(3-bromopropyl)-2,3-dihydro-1H-isoindol-1-one + dimethyl amine (124-40-3) → 3-benzylidene-2-[3-(dimethylamino)propyl]-2,3-dihydro-1H-isoindol-1-one (284685-12-7) + Z-3-benzylidene-2-[3-(dimethylamino)propyl]-2,3-dihydro-1H-isoindol-1-one (284685-13-8)

Guidance literature:

With potassium carbonate; potassium iodide; In N,N-dimethyl-formamide; at 100 ℃; for 3h; Overall yield = 58 %;

DOI:10.3762/bjoc.13.275

Reference yield:

phenylacetic acid (103-82-2) → 3-benzylidene-2-[3-(dimethylamino)propyl]-2,3-dihydro-1H-isoindol-1-one (284685-12-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 70 percent / AcONa / 4 h / 250 - 300 °C

2: ethanol / 4 h / Heating

3: formic acid / 0.5 h / 130 - 140 °C

With formic acid; sodium acetate; In ethanol; 1: Condensation / 2: Addition / 3: Elimination;

DOI:10.1021/jm991136e

upstream raw materials:

phenylacetic acid

phthalic anhydride

(Z)-3-benzylidenephthalide

dimethyl amine