2-(3-trifluoromethyl-phenyl)-cyclopropanecarboxylic acid ethyl ester

Base Information

• Chemical Name: 2-(3-trifluoromethyl-phenyl)-cyclopropanecarboxylic acid ethyl ester
• CAS No.: 1977-59-9
• Molecular Formula: C₁₃H₁₃F₃O₂
• Molecular Weight: 258.24
• Mol file: 1977-59-9.mol

Synonyms:2-(3-trifluoromethyl-phenyl)-cyclopropanecarboxylic acid ethyl ester

Chemical Property of 2-(3-trifluoromethyl-phenyl)-cyclopropanecarboxylic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 2-(3-trifluoromethyl-phenyl)-cyclopropanecarboxylic acid ethyl ester

There total 3 articles about 2-(3-trifluoromethyl-phenyl)-cyclopropanecarboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

(Diethylamino)dimethyloxosulfonium tetrafluoroborate (36501-44-7) + (E)-ethyl 3-(3-trifluoromethylphenyl)prop-2-enoate (116577-12-9,113048-68-3) → ethyl trans-2-cyclopropane-1-carboxylate (1977-59-9,114095-57-7)

Guidance literature:

With sodium hydride; In dimethyl sulfoxide; 1.) room temp., 2.) room temp., 72 h;

DOI:10.1021/ja00219a040

Reference yield:

diazoacetic acid ethyl ester (623-73-4) + 3-(trifluoromethyl)styrene (402-24-4) → ethyl trans-2-cyclopropane-1-carboxylate (1977-59-9,114095-57-7) + (1R,2S)-2-(3-Trifluoromethyl-phenyl)-cyclopropanecarboxylic acid ethyl ester

Guidance literature:

palladium diacetate;

DOI:10.1246/bcsj.71.685

Reference yield:

→ 2-(3-trifluoromethyl-phenyl)-cyclopropanecarboxylic acid ethyl ester (1977-59-9)

Guidance literature:

3-Trifluormethyl-styrol, Diazoessigsaeure-ethylester (2-6h, 170-190grad);

upstream raw materials:

(Diethylamino)dimethyloxosulfonium tetrafluoroborate

(E)-ethyl 3-(3-trifluoromethylphenyl)prop-2-enoate

diazoacetic acid ethyl ester

3-(trifluoromethyl)styrene

Downstream raw materials:

trans-2-(3-(trifluoromethyl)phenyl)cyclopropanecarboxylic acid

cis-<2-(m-(trifluoromethyl)phenyl)cyclopropyl>methyl acetate

trans-<2-cyclopropyl>methyl acetate

4--4-methoxy-1-butene