4(S)-butyl-4(S)-<(tert-butyloxycarbonyl)amino>-N-<4(S)-<(butylamino)carbonyl>-1(S)-(cyclohexylmethyl)-2(S)-hydroxy-5-methylhexyl>-1,3,4,5-tetrahydro-3-oxo-2H-2-benzazepine-2-acetamide

Base Information

Chemical Name:4(S)-butyl-4(S)-<(tert-butyloxycarbonyl)amino>-N-<4(S)-<(butylamino)carbonyl>-1(S)-(cyclohexylmethyl)-2(S)-hydroxy-5-methylhexyl>-1,3,4,5-tetrahydro-3-oxo-2H-2-benzazepine-2-acetamide
CAS No.:138571-24-1
Molecular Formula:C₄₀H₆₆N₄O₆
Molecular Weight:698.987
Hs Code.:

4(S)-butyl-4(S)-<(tert-butyloxycarbonyl)amino>-N-<4(S)-<(butylamino)carbonyl>-1(S)-(cyclohexylmethyl)-2(S)-hydroxy-5-methylhexyl>-1,3,4,5-tetrahydro-3-oxo-2H-2-benzazepine-2-acetamide

Synonyms:4(S)-butyl-4(S)-<(tert-butyloxycarbonyl)amino>-N-<4(S)-<(butylamino)carbonyl>-1(S)-(cyclohexylmethyl)-2(S)-hydroxy-5-methylhexyl>-1,3,4,5-tetrahydro-3-oxo-2H-2-benzazepine-2-acetamide

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Chemical Property of 4(S)-butyl-4(S)-<(tert-butyloxycarbonyl)amino>-N-<4(S)-<(butylamino)carbonyl>-1(S)-(cyclohexylmethyl)-2(S)-hydroxy-5-methylhexyl>-1,3,4,5-tetrahydro-3-oxo-2H-2-benzazepine-2-acetamide

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Technology Process of 4(S)-butyl-4(S)-<(tert-butyloxycarbonyl)amino>-N-<4(S)-<(butylamino)carbonyl>-1(S)-(cyclohexylmethyl)-2(S)-hydroxy-5-methylhexyl>-1,3,4,5-tetrahydro-3-oxo-2H-2-benzazepine-2-acetamide

There total 4 articles about 4(S)-butyl-4(S)-<(tert-butyloxycarbonyl)amino>-N-<4(S)-<(butylamino)carbonyl>-1(S)-(cyclohexylmethyl)-2(S)-hydroxy-5-methylhexyl>-1,3,4,5-tetrahydro-3-oxo-2H-2-benzazepine-2-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 138571-23-0
4(S)-amino-α(S)-butyl-N-<4(S)-<(butylamino)carbonyl>-1(S)-(cyclohexylmethyl)-2(S)-hydroxy-5-methylhexyl>-1,3,4,5-tetrahydro-3-oxo-2H-2-benzazepine-2-acetamide

: 138571-24-1
4(S)-butyl-4(S)-<(tert-butyloxycarbonyl)amino>-N-<4(S)-<(butylamino)carbonyl>-1(S)-(cyclohexylmethyl)-2(S)-hydroxy-5-methylhexyl>-1,3,4,5-tetrahydro-3-oxo-2H-2-benzazepine-2-acetamide

Guidance literature:: With triethylamine; In dichloromethane;
DOI:10.1021/jm00083a006

Reference yield:

: 105852-64-0
(2S,4S,5S)-5-amino-6-cyclohexyl-4-hydroxy-2-isopropyl hexanoic acid n-butyl amide

: 138571-24-1
4(S)-butyl-4(S)-<(tert-butyloxycarbonyl)amino>-N-<4(S)-<(butylamino)carbonyl>-1(S)-(cyclohexylmethyl)-2(S)-hydroxy-5-methylhexyl>-1,3,4,5-tetrahydro-3-oxo-2H-2-benzazepine-2-acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: 78 percent / N-hydroxybenzotriazole, 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride / CH₂Cl₂

2: 94 percent / hydrazine hydrate / ethanol / 1 h / Heating

3: 86 percent / triethylamine / CH₂Cl₂

With benzotriazol-1-ol; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In ethanol; dichloromethane;
DOI:10.1021/jm00083a006

Reference yield:

: 138571-21-8
4(S)-butyl-4(S)-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-1,3,4,5-tetrahydro-3-oxo-2H-2-benzazepine-2-acetic acid

: 138571-24-1
4(S)-butyl-4(S)-<(tert-butyloxycarbonyl)amino>-N-<4(S)-<(butylamino)carbonyl>-1(S)-(cyclohexylmethyl)-2(S)-hydroxy-5-methylhexyl>-1,3,4,5-tetrahydro-3-oxo-2H-2-benzazepine-2-acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: 78 percent / N-hydroxybenzotriazole, 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride / CH₂Cl₂

2: 94 percent / hydrazine hydrate / ethanol / 1 h / Heating

3: 86 percent / triethylamine / CH₂Cl₂

With benzotriazol-1-ol; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In ethanol; dichloromethane;
DOI:10.1021/jm00083a006