105852-64-0

Upstream product

• 105852-65-1 (2S)-2-[(4S,5S)-3-benzyloxycarbonyl-4-cyclohexylmethyl-2,2-dimethyl-1,3-oxazolidin-5-yl]methyl-N-butyl-3-methylbutanamide 
• 129921-94-4 N-butyl-2-(S)-((3-(tert-butyloxycarbonyl)-2,2-dimethyl-4(S)-(cyclohexylmethyl)-5(S)-oxazolidinyl)methyl)-3-methylbutanamide 
• 556-24-1 methyl 3-methylbutanoate 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 37736-82-6 (S)-2-tert-butoxycarbonylamino-3-cyclohexylpropionic acid 
• 117997-58-7 tert-butyl (4S,5R)-4-(cyclohexylmethyl)-5-formyl-2,2-dimethyl-3-oxazolidinecarboxylate 
• 115766-13-7 (S)-α-[[(1,1-dimethylethoxy)carbonyl]amino]-N-methoxy-N-methylcyclohexanepropanamide 
• 141258-90-4 (4S,5S)-5-((Z)-2-Butylcarbamoyl-3-methyl-but-1-enyl)-4-cyclohexylmethyl-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester 
• 141258-89-1 (4S,5S)-4-Cyclohexylmethyl-5-((Z)-2-methoxycarbonyl-3-methyl-but-1-enyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester 
• 169512-90-7 (S)-2-tert-Butoxycarbonylamino-3-cyclohexyl-propionic acid ethyl ester 
• 4522-04-7 ethyl N-{[(1,1-dimethylethyl)oxy]carbonyl}-L-phenylalaninate 
• 123580-22-3 [(S)-2-Cyclohexyl-1-((2S,4R)-4-isopropyl-5-oxo-tetrahydro-furan-2-yl)-ethyl]-carbamic acid tert-butyl ester 
• 124032-36-6 (3S,5S)-5-[(1S)-1-(t-butoxycarbonyl)amino-2-cyclohexylethyl]-3-isopropyldihydrofuran-2(3H)-one 
• 124032-43-5 [(S)-2-Cyclohexyl-1-((R)-4-isopropyl-5-oxo-2,5-dihydro-furan-2-yl)-ethyl]-carbamic acid tert-butyl ester 

Downstream Products

• 128923-35-3 (2S,4S,5S)-N-butyl-6-cyclohexyl-4-hydroxy-2-isopropyl-5-[8-propyl-6-(pyridin-3-yl)-1,2,4-triazolo[4,3-a]pyrazin-3-yl]acetamidohexanamide 
• 128901-36-0 (2S,4S,5S)-6-Cyclohexyl-4-hydroxy-2-isopropyl-5-[2-(8-propyl-6-pyridin-3-yl-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-3-pyridin-3-yl-propionylamino]-hexanoic acid butylamide 
• 128901-35-9 (2S,4S)-6-Cyclohexyl-4-hydroxy-5-[2-(8-isobutyl-6-phenyl-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-acetylamino]-2-isopropyl-hexanoic acid butylamide 
• 138571-26-3 N-<1-<<<4(S)-<(butylamino)carbonyl>-1(S)-(cyclohexylmethyl)-2(S)-hydroxy-5-methylhexyl>amino>carbonyl>pentyl>-1,3-dihydro-1,3-dioxo-α(S)-(phenylmethyl)-2H-isoindole-2-acetamide 
• 138571-22-9 4(S)-butyl-N-<4(S)-<(butylamino)carbonyl>-1(S)-(cyclohexylmethyl)-2(S)-hydroxy-5-methylhexyl>-4(S)-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-1,3,4,5-tetrahydro-3-oxo-2H-2-benzazepine-2-acetamide 
• 138571-14-9 3(S)-azido-α(S)-butyl-N-<4(S)-<(butylamino)carbonyl>-1(S)-(cyclohexylmethyl)-2(S)-hydroxy-5-methylhexyl>-2-oxo-4(R)-phenyl-1-piperidineacetamide 
• 138662-94-9 3(S)-azido-α(S)-butyl-N-<4(S)-<(butylamino)carbonyl>-1(S)-(cyclohexylmethyl)-2(S)-hydroxy-5-methylhexyl>-2-oxo-4(S)-phenyl-1-piperidineacetamide 
• 143117-79-7 [(S)-1-((1S,2S,4S)-4-Butylcarbamoyl-1-cyclohexylmethyl-2-hydroxy-5-methyl-hexylcarbamoyl)-2-(1H-imidazol-4-yl)-ethyl]-carbamic acid tert-butyl ester 
• 114469-22-6 (2S,4S,5S)-5-[(S)-2-[(S)-2-Benzyl-3-(2-methyl-propane-2-sulfonyl)-propionylamino]-3-(1H-imidazol-4-yl)-propionylamino]-6-cyclohexyl-4-hydroxy-2-isopropyl-hexanoic acid butylamide 
• 105852-62-8 (2S,4S,5S)-5-[(S)-2-Amino-3-(1H-imidazol-4-yl)-propionylamino]-6-cyclohexyl-4-hydroxy-2-isopropyl-hexanoic acid butylamide 
• 105851-89-6 2,2-Dimethyl-propionic acid (S)-1-[(S)-1-((1S,2S,4S)-4-butylcarbamoyl-1-cyclohexylmethyl-2-hydroxy-5-methyl-hexylcarbamoyl)-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-2-phenyl-ethyl ester 
• 114530-03-9 (2S,4S,5S)-5-[(S)-2-[(R)-2-Benzyl-3-(2-methyl-propane-2-sulfonyl)-propionylamino]-3-(1H-imidazol-4-yl)-propionylamino]-6-cyclohexyl-4-hydroxy-2-isopropyl-hexanoic acid butylamide 
• 138571-24-1 4(S)-butyl-4(S)-<(tert-butyloxycarbonyl)amino>-N-<4(S)-<(butylamino)carbonyl>-1(S)-(cyclohexylmethyl)-2(S)-hydroxy-5-methylhexyl>-1,3,4,5-tetrahydro-3-oxo-2H-2-benzazepine-2-acetamide 
• 138571-28-5 N-<(1,1-dimethylethoxy)carbonyl>-L-phenylalanyl-N-<4(S)-<(butylamino)carbonyl>-1(S)-(cyclohexylmethyl)-2(S)-hydroxy-5-methylhexyl>-L-norleucinamide 

Relevant academic research and scientific papers

Synthesis of the hydroxyethylene dipeptide isostere, (2S,4S,5S)-5-amino-6-cyclohexyl-4-hydroxy-2-isopropyl hexanoic acid n-butyl amide

A stereoselective synthesis of the hydroxyethylene dipeptide isostere, (2S,4S,5S)-5-amino-6-cyclohexyl-4-hydroxy-2-isopropyl hexanoic acid-n-butyl amide from Boc-L-phenylalanine is described.

5-(HETEROCYCLYLALKANOYL)AMINO-4-HYDROXYPENTANAMIDES

This invention concerns novel nitrogen derivatives of the formula I STR1 (and their pharmaceutically-acceptable salts), together with pharmaceutical compositions containing them. The nitrogen derivatives are inhibitors of the catalytic action of renin. Th

1,2,4-Triazolopyrazine Derivatives with Human Renin Inhibitory Activity. 2. Synthesis, Biological Properties and Molecular Modeling of Hydroxyethylene Isostere Derivatives

A series of inhibitors of human renin have been synthesized, derived from combination of a 2-(8-propyl-6-pyridin-3-yl-1,2,4-triazolopyrazin-3-yl)-3-pyridin-3-ylpropionic acid moiety 6c with the hydroxyethylene isostere of the scissile amide bond (2

THE SYNTHESIS OF (2S,4S,5S)-5-(N-BOC)-AMINO-6-CYCLOHEXYL-4-HYDORXY-2-ISOPROPYL-HEXANOIC ACID LACTONE, AN HYDROXYETHYLENE DIPEPTIDE ISOSTERE PRECURSOR

(2SR,4SR)-5-(S)-(N-Boc)-amino-cyclohexyl-4-hydroxy-2-isopropyl hexanoivc acid from (L)-phenylalanine and the preparation of the n-butyl amide of the 2(S),4(S),5(S) acid is presented.

A Versatile and Stereocontrolled Synthesis of Hydroxyethylene Dipeptide Isosteres

An asymmetric synthesis of the hydroxyethylene dipeptide isostere unit 1 is described.The synthesis provides excellent stereocontrol over all three chiral centers and is amenable to variation of substituents R1 and R2.Key intermediat

Synthesis and biological activity of some transition-state inhibitors of human renin

A series of renin inhibitors containing the dipeptide transition state mimics (2S,4S,5S)-5-amino-4-hydroxy-2-isopropyl-7-methyloctanoic acid (Leu-(OH)-Val) and (2S,4S,5S)-5-amino-4-hydroxy-2-isopropyl-6-cyclohexylhexanoic acid (Cha-(OH)-Val) was prepared.