1-phenyl-1,2-epoxyphosphonate

Base Information

• Chemical Name: 1-phenyl-1,2-epoxyphosphonate
• CAS No.: 1021-15-4
• Molecular Formula: C₁₂H₁₇O₄P
• Molecular Weight: 256.238
• Mol file: 1021-15-4.mol

Synonyms:1-phenyl-1,2-epoxyphosphonate

Chemical Property of 1-phenyl-1,2-epoxyphosphonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-phenyl-1,2-epoxyphosphonate

There total 2 articles about 1-phenyl-1,2-epoxyphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

1-chloroacetophenone (532-27-4,108321-66-0,164322-25-2) + phosphonic acid diethyl ester (762-04-9) → 1-phenyl-1,2-epoxyphosphonate (1021-15-4) + phosphoric acid diethyl ester-(1-phenyl-vinyl ester) (1021-45-0)

Guidance literature:

With potassium fluoride; In N,N-dimethyl-formamide; for 17h;

DOI:10.1016/S0040-4039(00)78986-6

Reference yield: 20.0%

diethyl α-(chloromethyl)-α-<(trimethylsilyl)oxy>benzylphosphonate (78610-05-6) → 1-phenyl-1,2-epoxyphosphonate (1021-15-4) + phosphoric acid diethyl ester-(1-phenyl-vinyl ester) (1021-45-0) + 1-chloroacetophenone (532-27-4,108321-66-0,164322-25-2)

Guidance literature:

With tetrabutyl ammonium fluoride; In dichloromethane; for 0.5h; Mechanism; Product distribution; Ambient temperature; other reaction time;

DOI:10.1021/jo00333a018

upstream raw materials:

diethyl α-(chloromethyl)-α-<(trimethylsilyl)oxy>benzylphosphonate

1-chloroacetophenone

phosphonic acid diethyl ester