4-nitrophenyl 4-((6,7-dimethoxyquinolin-4-yl)oxy)-3-fluorophenylcarbamate

Base Information

Chemical Name:4-nitrophenyl 4-((6,7-dimethoxyquinolin-4-yl)oxy)-3-fluorophenylcarbamate
CAS No.:1000850-83-8
Molecular Formula:C₂₄H₁₈FN₃O₇
Molecular Weight:479.421
Hs Code.:

Synonyms:4-nitrophenyl 4-((6,7-dimethoxyquinolin-4-yl)oxy)-3-fluorophenylcarbamate

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Chemical Property of 4-nitrophenyl 4-((6,7-dimethoxyquinolin-4-yl)oxy)-3-fluorophenylcarbamate

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Technology Process of 4-nitrophenyl 4-((6,7-dimethoxyquinolin-4-yl)oxy)-3-fluorophenylcarbamate

There total 1 articles about 4-nitrophenyl 4-((6,7-dimethoxyquinolin-4-yl)oxy)-3-fluorophenylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 7693-46-1
4-Nitrophenyl chloroformate

: 347161-74-4
4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-fluoroaniline

: 1000850-83-8
4-nitrophenyl 4-((6,7-dimethoxyquinolin-4-yl)oxy)-3-fluorophenylcarbamate

Guidance literature:: In dichloromethane; at 20 ℃; for 1h; Alkaline conditions; Inert atmosphere;
DOI:10.1021/jm201330u

Reference yield: 32.0%

: 1848-69-7
1-phenylimidazolidin-2-one

: 1000850-83-8
4-nitrophenyl 4-((6,7-dimethoxyquinolin-4-yl)oxy)-3-fluorophenylcarbamate

: N-(4-((6,7-dimethoxyquinolin-4-yl)oxy)-3-fluorophenyl)-2-oxo-3-phenylimidazolidine-1-carboxamide

Guidance literature:: 1-phenylimidazolidin-2-one; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 0.25h; Inert atmosphere;

4-nitrophenyl 4-((6,7-dimethoxyquinolin-4-yl)oxy)-3-fluorophenylcarbamate; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 0.666667h;
DOI:10.1021/jm201330u