Acetamide, N-(4-azidophenyl)-

Base Information

• Chemical Name: Acetamide, N-(4-azidophenyl)-
• CAS No.: 52578-66-2
• Molecular Formula: C8H8 N4 O
• Molecular Weight: 176.178
• NSC Number: 80925
• DSSTox Substance ID: DTXSID20401853
• Nikkaji Number: J847.691H
• Wikidata: Q82205118
• ChEMBL ID: CHEMBL3892504
• Mol file: 52578-66-2.mol

Synonyms:N-(4-azidophenyl)acetamide;Acetamide, N-(4-azidophenyl)-;52578-66-2;CHEMBL3892504;SCHEMBL13556976;DTXSID20401853;NSC80925;BDBM50200115;CCG-40395;NSC-80925

Chemical Property of Acetamide, N-(4-azidophenyl)-

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Density: g/cm³
• XLogP3: 2.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 176.06981089
• Heavy Atom Count: 13
• Complexity: 226

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)NC1=CC=C(C=C1)N=[N+]=[N-]

Technology Process of Acetamide, N-(4-azidophenyl)-

There total 12 articles about Acetamide, N-(4-azidophenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

4-bromoacetanilide (103-88-8) → p-(acetylamino)phenyl azide (52578-66-2)

Guidance literature:

With sodium azide; copper; diisopropylamine; L-proline; In ethanol; water; at 100 ℃; for 25h; Sealed tube;

DOI:10.14233/ajchem.2015.17551

Reference yield: 49.0%

4-azidoaniline (14860-64-1) + acetic anhydride (108-24-7) → p-(acetylamino)phenyl azide (52578-66-2)

Guidance literature:

With hydrogenchloride; sodium acetate; for 0.25h;

Reference yield: 48.0%

4-Acetamido-1-iodobenzene (622-50-4) → p-(acetylamino)phenyl azide (52578-66-2)

Guidance literature:

With sodium azide; copper; diisopropylamine; ascorbic acid; In dimethyl sulfoxide; at 80 ℃; for 24h;

DOI:10.1016/j.jorganchem.2013.10.005

upstream raw materials:

4-azidoaniline

acetic anhydride

1,4-phenylenediamine

4-Acetamido-1-iodobenzene

Downstream raw materials:

4-azidoaniline

4-(N-acetylamino)-1-nitrosobezene