(3-(4-ethyl-benzyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-fluoro-4-morpholin-4-yl-phenyl)-amine

Base Information

• Chemical Name: (3-(4-ethyl-benzyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-fluoro-4-morpholin-4-yl-phenyl)-amine
• CAS No.: 850808-54-7
• Molecular Formula: C₂₅H₃₂FN₃O
• Molecular Weight: 409.547

Synonyms:(3-(4-ethyl-benzyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-fluoro-4-morpholin-4-yl-phenyl)-amine

Chemical Property of (3-(4-ethyl-benzyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-fluoro-4-morpholin-4-yl-phenyl)-amine

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Technology Process of (3-(4-ethyl-benzyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-fluoro-4-morpholin-4-yl-phenyl)-amine

There total 2 articles about (3-(4-ethyl-benzyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-fluoro-4-morpholin-4-yl-phenyl)-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C15H19NO (1144092-90-9) + 3-fluoro-4-(morpholinyl)aniline (93246-53-8) → (3-(4-ethyl-benzyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-fluoro-4-morpholin-4-yl-phenyl)-amine (850808-54-7)

Guidance literature:

With sodium cyanoborohydride; acetic acid; In methanol; at 20 ℃; for 1h;

Reference yield:

(3-azabicyclo[3.1.0]hex-6-yl)methanol (289037-48-5) → (3-(4-ethyl-benzyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-fluoro-4-morpholin-4-yl-phenyl)-amine (850808-54-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium cyanoborohydride / methanol / 3 h / 20 °C

2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.5 h / -78 °C

2.2: 1 h / -78 - 0 °C

3.1: sodium cyanoborohydride; acetic acid / methanol / 1 h / 20 °C

With oxalyl dichloride; sodium cyanoborohydride; acetic acid; dimethyl sulfoxide; In methanol; dichloromethane;

Reference yield:

benzothiophene-2-carboxylic acid chloride (39827-11-7) + (3-(4-ethyl-benzyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-fluoro-4-morpholin-4-yl-phenyl)-amine (850808-54-7) → benzo[b]thiophene-2-carboxylic acid [3-(4-ethyl-benzyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-fluoro-4-morpholin-4-yl-phenyl)-amide (850808-56-9)

Guidance literature:

With dmap; N-ethyl-N,N-diisopropylamine; In 1,2-dichloro-ethane; at 20 ℃; for 1h;

upstream raw materials:

C₁₅H₁₉NO

3-fluoro-4-(morpholinyl)aniline

(3-azabicyclo[3.1.0]hex-6-yl)methanol

Downstream raw materials:

benzo[b]thiophene-2-carboxylic acid [3-(4-ethyl-benzyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-fluoro-4-morpholin-4-yl-phenyl)-amide

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