benzo[b]thiophene-2-carboxylic acid [3-(4-ethyl-benzyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-fluoro-4-morpholin-4-yl-phenyl)-amide

Base Information

• Chemical Name: benzo[b]thiophene-2-carboxylic acid [3-(4-ethyl-benzyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-fluoro-4-morpholin-4-yl-phenyl)-amide
• CAS No.: 850808-56-9
• Molecular Formula: C₃₄H₃₆FN₃O₂S
• Molecular Weight: 569.743

Synonyms:benzo[b]thiophene-2-carboxylic acid [3-(4-ethyl-benzyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-fluoro-4-morpholin-4-yl-phenyl)-amide

Chemical Property of benzo[b]thiophene-2-carboxylic acid [3-(4-ethyl-benzyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-fluoro-4-morpholin-4-yl-phenyl)-amide

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Technology Process of benzo[b]thiophene-2-carboxylic acid [3-(4-ethyl-benzyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-fluoro-4-morpholin-4-yl-phenyl)-amide

There total 2 articles about benzo[b]thiophene-2-carboxylic acid [3-(4-ethyl-benzyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-fluoro-4-morpholin-4-yl-phenyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzothiophene-2-carboxylic acid chloride (39827-11-7) + (3-(4-ethyl-benzyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-fluoro-4-morpholin-4-yl-phenyl)-amine (850808-54-7) → benzo[b]thiophene-2-carboxylic acid [3-(4-ethyl-benzyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-fluoro-4-morpholin-4-yl-phenyl)-amide (850808-56-9)

Guidance literature:

With dmap; N-ethyl-N,N-diisopropylamine; In 1,2-dichloro-ethane; at 20 ℃; for 1h;

Reference yield:

(3-azabicyclo[3.1.0]hex-6-yl)methanol (289037-48-5) → benzo[b]thiophene-2-carboxylic acid [3-(4-ethyl-benzyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-fluoro-4-morpholin-4-yl-phenyl)-amide (850808-56-9)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium cyanoborohydride / methanol / 3 h / 20 °C

2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.5 h / -78 °C

2.2: 1 h / -78 - 0 °C

3.1: sodium cyanoborohydride; acetic acid / methanol / 1 h / 20 °C

4.1: dmap; N-ethyl-N,N-diisopropylamine / 1,2-dichloro-ethane / 1 h / 20 °C

With dmap; oxalyl dichloride; sodium cyanoborohydride; acetic acid; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; 1,2-dichloro-ethane;

upstream raw materials:

benzothiophene-2-carboxylic acid chloride

(3-(4-ethyl-benzyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-fluoro-4-morpholin-4-yl-phenyl)-amine

(3-azabicyclo[3.1.0]hex-6-yl)methanol

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