Technology Process of C18H16BrFN4O
There total 10 articles about C18H16BrFN4O which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2-(4-bromo-3-fluorophenyl)-N-[2-(2-methoxypyridin-4-yl)ethyl]-6-methylpyrimidin-4-amine;
With
hydrogen bromide;
In
water;
at 80 ℃;
for 72h;
With
sodium hydrogencarbonate;
In
water; ethyl acetate;
at 20 ℃;
DOI:10.1016/j.bmc.2012.06.049
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: hydrogen; ammonium hydroxide / ethanol / 22 h / 20 °C
2.1: 1,3-dimethyl-2-imidazolidinone; potassium carbonate / 95 °C
3.1: hydrogen bromide / water / 72 h / 80 °C
3.2: 20 °C
With
1,3-dimethyl-2-imidazolidinone; ammonium hydroxide; hydrogen bromide; hydrogen; potassium carbonate;
In
ethanol; water;
DOI:10.1016/j.bmc.2012.06.049
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: 1,4-dioxane / 26 h / Reflux
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 °C / Inert atmosphere
3.1: thionyl chloride / 2.25 h / 0 °C
4.1: 18-crown-6 ether / acetonitrile / 13 h / 20 °C
5.1: hydrogen; ammonium hydroxide / ethanol / 22 h / 20 °C
6.1: 1,3-dimethyl-2-imidazolidinone; potassium carbonate / 95 °C
7.1: hydrogen bromide / water / 72 h / 80 °C
7.2: 20 °C
With
1,3-dimethyl-2-imidazolidinone; ammonium hydroxide; lithium aluminium tetrahydride; thionyl chloride; 18-crown-6 ether; hydrogen bromide; hydrogen; potassium carbonate;
In
tetrahydrofuran; 1,4-dioxane; ethanol; water; acetonitrile;
DOI:10.1016/j.bmc.2012.06.049
![2-(4-bromo-3-fluorophenyl)-N-[2-(2-methoxypyridin-4-yl)ethyl]-6-methylpyrimidin-4-amine](/Databaselist/images/loading.webp)
