4-Pyridinemethanol,2-methoxy-(9CI)

Base Information

• Chemical Name: 4-Pyridinemethanol,2-methoxy-(9CI)
• CAS No.: 123148-66-3
• Molecular Formula: C7H9NO2
• Molecular Weight: 139.154
• Hs Code.: 2933399090
• Mol file: 123148-66-3.mol

Synonyms:(2-Methoxypyridin-4-yl)methanol;2-Methoxy-4-pyridinemethanol;

Chemical Property of 4-Pyridinemethanol,2-methoxy-(9CI)

Chemical Property:

• Vapor Pressure: 0.0067mmHg at 25°C
• Refractive Index: 1.534
• Boiling Point: 259.2 °C at 760 mmHg
• Flash Point: 110.6 °C
• PSA: 42.35000
• Density: 1.155 g/cm³
• LogP: 0.58250
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

(2-Methoxypyridin-4-yl)methanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Pyridinemethanol,2-methoxy-(9CI)

There total 11 articles about 4-Pyridinemethanol,2-methoxy-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-methoxypyridine-4-methyl methoxymethyl ether (754218-84-3) → 2-methoxy-4-(hydroxymethyl)-pyridine (123148-66-3)

Guidance literature:

2-methoxypyridine-4-methyl methoxymethyl ether; With hydrogenchloride; In ethyl acetate; at 0 ℃; for 0.5h;

With sodium hydrogencarbonate; In chloroform; water; ethyl acetate;

Reference yield: 93.0%

2-methoxy-isonicotinic acid (105596-63-2) → 2-methoxy-4-(hydroxymethyl)-pyridine (123148-66-3)

Guidance literature:

2-methoxy-isonicotinic acid; With 4-methyl-morpholine; chloroformic acid ethyl ester; In tetrahydrofuran; at 0 ℃; for 0.333333h;

With sodium tetrahydroborate; In tetrahydrofuran; methanol; at 20 ℃; for 16h;

Reference yield: 89.0%

ethyl 2-methoxy-pyridine-4-carboxylate (105596-61-0) → 2-methoxy-4-(hydroxymethyl)-pyridine (123148-66-3)

Guidance literature:

In water;

upstream raw materials:

methyl 2-methoxyisonicotinate

(2-chloropyridin-4-yl)methanol

sodium methylate

ethyl 2-methoxy-pyridine-4-carboxylate

Downstream raw materials:

2-methoxypyridine-4-carboxaldehyde

2-(2-methoxypyridin-4-yl)ethylamine

2-(4-bromo-3-fluorophenyl)-N-[2-(2-methoxypyridin-4-yl)ethyl]-6-methylpyrimidin-4-amine

C₁₈H₁₆BrFN₄O

Refernces

• 1、 Tan, Liang,Tao, Yunliang,Wang, Ting,Zou, Feng,Zhang, Shuhua,Kou, Qunhuan,Niu, Ao,Chen, Qian,Chu, Wenjing,Chen, Xiaoyan,Wang, Haidong,Yang, Yushe. "Discovery of Novel Pyridone-Conjugated Monosulfactams as Potent and Broad-Spectrum Antibiotics for Multidrug-Resistant Gram-Negative Infections". supporting information. p. 2669 - 2684. Retrieved 2017/04/21.
• 2、 -. "Compounds Useful as Immunomodulators". Paragraph 1148; 1149. . Retrieved 2015/11/03.