N-(7-cyano-6-{4-fluoro-3-[(trifluoroacetyl)amino]phenoxy}-1,3-benzothiazol-2-yl)cyclopropanecarboxamide

Base Information

Chemical Name:N-(7-cyano-6-{4-fluoro-3-[(trifluoroacetyl)amino]phenoxy}-1,3-benzothiazol-2-yl)cyclopropanecarboxamide
CAS No.:1228590-90-6
Molecular Formula:C₂₀H₁₂F₄N₄O₃S
Molecular Weight:464.4
Hs Code.:

Synonyms:N-(7-cyano-6-{4-fluoro-3-[(trifluoroacetyl)amino]phenoxy}-1,3-benzothiazol-2-yl)cyclopropanecarboxamide

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Chemical Property of N-(7-cyano-6-{4-fluoro-3-[(trifluoroacetyl)amino]phenoxy}-1,3-benzothiazol-2-yl)cyclopropanecarboxamide

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Technology Process of N-(7-cyano-6-{4-fluoro-3-[(trifluoroacetyl)amino]phenoxy}-1,3-benzothiazol-2-yl)cyclopropanecarboxamide

There total 6 articles about N-(7-cyano-6-{4-fluoro-3-[(trifluoroacetyl)amino]phenoxy}-1,3-benzothiazol-2-yl)cyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1228590-89-3
N-(5-((2-amino-7-cyanobenzo[d]thiazol-6-yl)oxy)-2-fluorophenyl)-2,2,2-trifluoroacetamide

: 4023-34-1
cyclopropanecarboxylic acid chloride

: 1228590-90-6
N-(7-cyano-6-{4-fluoro-3-[(trifluoroacetyl)amino]phenoxy}-1,3-benzothiazol-2-yl)cyclopropanecarboxamide

Guidance literature:: With pyridine; In tetrahydrofuran; at 20 ℃;
DOI:10.1021/jm400778d

Reference yield:

: 62257-16-3
5-hydroxy-2-fluoroaniline

: 1228590-90-6
N-(7-cyano-6-{4-fluoro-3-[(trifluoroacetyl)amino]phenoxy}-1,3-benzothiazol-2-yl)cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 60 °C

2.1: tetrahydrofuran / 0 - 20 °C

3.1: hydrogen; palladium 10% on activated carbon / methanol / 20 °C / 760.05 Torr

4.1: acetic acid / 0.17 h / 20 °C

4.2: 12 h / 20 °C

5.1: pyridine / tetrahydrofuran / 20 °C

With pyridine; palladium 10% on activated carbon; hydrogen; potassium carbonate; acetic acid; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm400778d

Reference yield:

: 1228590-88-2
N-[5-(4-amino-2-cyanophenoxy)-2-fluorophenyl]-2,2,2-trifluoroacetamide

: 1228590-90-6
N-(7-cyano-6-{4-fluoro-3-[(trifluoroacetyl)amino]phenoxy}-1,3-benzothiazol-2-yl)cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: acetic acid / 0.17 h / 20 °C

1.2: 12 h / 20 °C

2.1: pyridine / tetrahydrofuran / 20 °C

With pyridine; acetic acid; In tetrahydrofuran;
DOI:10.1021/jm400778d