N-[5-(4-amino-2-cyanophenoxy)-2-fluorophenyl]-2,2,2-trifluoroacetamide

Base Information

Chemical Name:N-[5-(4-amino-2-cyanophenoxy)-2-fluorophenyl]-2,2,2-trifluoroacetamide
CAS No.:1228590-88-2
Molecular Formula:C₁₅H₉F₄N₃O₂
Molecular Weight:339.249
Hs Code.:

Synonyms:N-[5-(4-amino-2-cyanophenoxy)-2-fluorophenyl]-2,2,2-trifluoroacetamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[5-(4-amino-2-cyanophenoxy)-2-fluorophenyl]-2,2,2-trifluoroacetamide

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Technology Process of N-[5-(4-amino-2-cyanophenoxy)-2-fluorophenyl]-2,2,2-trifluoroacetamide

There total 4 articles about N-[5-(4-amino-2-cyanophenoxy)-2-fluorophenyl]-2,2,2-trifluoroacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1228590-87-1
N-[5-(2-cyano-4-nitrophenoxy)-2-fluorophenyl]-2,2,2-trifluoroacetamide

: 1228590-88-2
N-[5-(4-amino-2-cyanophenoxy)-2-fluorophenyl]-2,2,2-trifluoroacetamide

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In methanol; at 20 ℃; for 2h; under 760.051 Torr;

Reference yield:

: 62257-16-3
5-hydroxy-2-fluoroaniline

: 1228590-88-2
N-[5-(4-amino-2-cyanophenoxy)-2-fluorophenyl]-2,2,2-trifluoroacetamide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 60 °C

2: tetrahydrofuran / 0 - 20 °C

3: hydrogen; palladium 10% on activated carbon / methanol / 20 °C / 760.05 Torr

With palladium 10% on activated carbon; hydrogen; potassium carbonate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm400778d

Reference yield:

: 1228590-86-0
2-(3-amino-4-fluorophenoxy)-5-nitrobenzonitrile

: 1228590-88-2
N-[5-(4-amino-2-cyanophenoxy)-2-fluorophenyl]-2,2,2-trifluoroacetamide

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran / 0 - 20 °C

2: hydrogen; palladium 10% on activated carbon / methanol / 20 °C / 760.05 Torr

With palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; methanol;
DOI:10.1021/jm400778d