1-benzenesulfonyl-5-chloro-3-[methyl-3-((E)-2-cyanovinyl)-5-methylphenyl]phosphinoyl-1H-indole-2-carboxylic acid ethyl ester

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Chemical Name:1-benzenesulfonyl-5-chloro-3-[methyl-3-((E)-2-cyanovinyl)-5-methylphenyl]phosphinoyl-1H-indole-2-carboxylic acid ethyl ester
CAS No.:1018450-13-9
Molecular Formula:C₂₈H₂₄ClN₂O₆PS
Molecular Weight:583.001
Hs Code.:

Synonyms:1-benzenesulfonyl-5-chloro-3-[methyl-3-((E)-2-cyanovinyl)-5-methylphenyl]phosphinoyl-1H-indole-2-carboxylic acid ethyl ester

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Chemical Property of 1-benzenesulfonyl-5-chloro-3-[methyl-3-((E)-2-cyanovinyl)-5-methylphenyl]phosphinoyl-1H-indole-2-carboxylic acid ethyl ester

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Technology Process of 1-benzenesulfonyl-5-chloro-3-[methyl-3-((E)-2-cyanovinyl)-5-methylphenyl]phosphinoyl-1H-indole-2-carboxylic acid ethyl ester

There total 4 articles about 1-benzenesulfonyl-5-chloro-3-[methyl-3-((E)-2-cyanovinyl)-5-methylphenyl]phosphinoyl-1H-indole-2-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67-56-1
methanol

: 1018450-13-9
1-benzenesulfonyl-5-chloro-3-[methyl-3-((E)-2-cyanovinyl)-5-methylphenyl]phosphinoyl-1H-indole-2-carboxylic acid ethyl ester

Guidance literature:: C₂₉H₂₆ClN₂O₆PS; With trimethylsilyl bromide; In dichloromethane; at 0 - 40 ℃; for 1.75h;

With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 0 ℃; for 1.25h;

methanol; In dichloromethane; at 0 - 20 ℃; for 2h; Product distribution / selectivity;

Reference yield:

: C₁₁H₁₂NO₂P

: 1018450-09-3
ethyl 1-phenylsulfonyl-5-chloro-3-iodo-1H-indole-2-carboxylate

: 1018450-13-9
1-benzenesulfonyl-5-chloro-3-[methyl-3-((E)-2-cyanovinyl)-5-methylphenyl]phosphinoyl-1H-indole-2-carboxylic acid ethyl ester

Guidance literature:: With triethylamine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In N,N-dimethyl-formamide; at 70 - 90 ℃; Product distribution / selectivity;

Reference yield:

: 881924-59-0
ethyl 3-bromo-5-chloro-1-(phenylsulfonyl)-1H-indole-2-carboxylate

: 1018450-13-9
1-benzenesulfonyl-5-chloro-3-[methyl-3-((E)-2-cyanovinyl)-5-methylphenyl]phosphinoyl-1H-indole-2-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: anilinium hypophosphite; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / ethyl acetate / 77 °C

2: potassium carbonate / 2 h / Large scale

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; anilinium hypophosphite; In ethyl acetate;
DOI:10.1021/acs.oprd.7b00356