S-6-[bis(4-methoxyphenyl)(phenyl)methoxy]hexyl-O-1-(2-nitrophenyl)-2-(4-pentynamido)ethyl carbonothioate

Base Information

Chemical Name:S-6-[bis(4-methoxyphenyl)(phenyl)methoxy]hexyl-O-1-(2-nitrophenyl)-2-(4-pentynamido)ethyl carbonothioate
CAS No.:1402719-28-1
Molecular Formula:C₄₁H₄₄N₂O₈S
Molecular Weight:724.875
Hs Code.:

Synonyms:S-6-[bis(4-methoxyphenyl)(phenyl)methoxy]hexyl-O-1-(2-nitrophenyl)-2-(4-pentynamido)ethyl carbonothioate

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Chemical Property of S-6-[bis(4-methoxyphenyl)(phenyl)methoxy]hexyl-O-1-(2-nitrophenyl)-2-(4-pentynamido)ethyl carbonothioate

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Technology Process of S-6-[bis(4-methoxyphenyl)(phenyl)methoxy]hexyl-O-1-(2-nitrophenyl)-2-(4-pentynamido)ethyl carbonothioate

There total 6 articles about S-6-[bis(4-methoxyphenyl)(phenyl)methoxy]hexyl-O-1-(2-nitrophenyl)-2-(4-pentynamido)ethyl carbonothioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1402719-27-0
(S)-6-hydroxyhexyl-O-1-(2-nitrophenyl)-2-(4-pentynamido)ethylcarbonothioate

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 1402719-28-1
S-6-[bis(4-methoxyphenyl)(phenyl)methoxy]hexyl-O-1-(2-nitrophenyl)-2-(4-pentynamido)ethyl carbonothioate

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 0.5h; Inert atmosphere;
DOI:10.1002/chem.201103833

Reference yield:

: 73685-71-9
1-(o-nitrophenyl)-2-aminoethanol

: 1402719-28-1
S-6-[bis(4-methoxyphenyl)(phenyl)methoxy]hexyl-O-1-(2-nitrophenyl)-2-(4-pentynamido)ethyl carbonothioate

Guidance literature:: Multi-step reaction with 4 steps

1.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 1 h / 20 °C

1.2: 3 h / 20 °C

2.1: dmap / acetonitrile / 0.5 h / 20 °C / Inert atmosphere

3.1: acetonitrile / 1.5 h / Inert atmosphere

4.1: triethylamine / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

With dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1002/chem.201103833

Reference yield:

: 35947-93-4
2-azido-1-(2-nitrophenyl)ethan-1-one

: 1402719-28-1
S-6-[bis(4-methoxyphenyl)(phenyl)methoxy]hexyl-O-1-(2-nitrophenyl)-2-(4-pentynamido)ethyl carbonothioate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium tetrahydroborate / 1,4-dioxane; methanol / 0 - 20 °C

2.1: triphenylphosphine / 0 - 20 °C

3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 1 h / 20 °C

3.2: 3 h / 20 °C

4.1: dmap / acetonitrile / 0.5 h / 20 °C / Inert atmosphere

5.1: acetonitrile / 1.5 h / Inert atmosphere

6.1: triethylamine / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

With dmap; sodium tetrahydroborate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1002/chem.201103833