(S)-6-hydroxyhexyl-O-1-(2-nitrophenyl)-2-(4-pentynamido)ethylcarbonothioate

Base Information

Chemical Name:(S)-6-hydroxyhexyl-O-1-(2-nitrophenyl)-2-(4-pentynamido)ethylcarbonothioate
CAS No.:1402719-27-0
Molecular Formula:C₂₀H₂₆N₂O₆S
Molecular Weight:422.502
Hs Code.:

Synonyms:(S)-6-hydroxyhexyl-O-1-(2-nitrophenyl)-2-(4-pentynamido)ethylcarbonothioate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-6-hydroxyhexyl-O-1-(2-nitrophenyl)-2-(4-pentynamido)ethylcarbonothioate

Chemical Property:

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Technology Process of (S)-6-hydroxyhexyl-O-1-(2-nitrophenyl)-2-(4-pentynamido)ethylcarbonothioate

There total 5 articles about (S)-6-hydroxyhexyl-O-1-(2-nitrophenyl)-2-(4-pentynamido)ethylcarbonothioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 73685-71-9
1-(o-nitrophenyl)-2-aminoethanol

: 1402719-27-0
(S)-6-hydroxyhexyl-O-1-(2-nitrophenyl)-2-(4-pentynamido)ethylcarbonothioate

Guidance literature:: Multi-step reaction with 3 steps

1.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 1 h / 20 °C

1.2: 3 h / 20 °C

2.1: dmap / acetonitrile / 0.5 h / 20 °C / Inert atmosphere

3.1: acetonitrile / 1.5 h / Inert atmosphere

With dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; acetonitrile;
DOI:10.1002/chem.201103833

Reference yield:

: 35947-93-4
2-azido-1-(2-nitrophenyl)ethan-1-one

: 1402719-27-0
(S)-6-hydroxyhexyl-O-1-(2-nitrophenyl)-2-(4-pentynamido)ethylcarbonothioate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium tetrahydroborate / 1,4-dioxane; methanol / 0 - 20 °C

2.1: triphenylphosphine / 0 - 20 °C

3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 1 h / 20 °C

3.2: 3 h / 20 °C

4.1: dmap / acetonitrile / 0.5 h / 20 °C / Inert atmosphere

5.1: acetonitrile / 1.5 h / Inert atmosphere

With dmap; sodium tetrahydroborate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; In 1,4-dioxane; methanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1002/chem.201103833

Reference yield:

: 6851-99-6
2-bromo-1-(2-nitrophenyl)ethanone

: 1402719-27-0
(S)-6-hydroxyhexyl-O-1-(2-nitrophenyl)-2-(4-pentynamido)ethylcarbonothioate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium azide / acetone / 0 - 20 °C

2.1: sodium tetrahydroborate / 1,4-dioxane; methanol / 0 - 20 °C

3.1: triphenylphosphine / 0 - 20 °C

4.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 1 h / 20 °C

4.2: 3 h / 20 °C

5.1: dmap / acetonitrile / 0.5 h / 20 °C / Inert atmosphere

6.1: acetonitrile / 1.5 h / Inert atmosphere

With dmap; sodium tetrahydroborate; sodium azide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; In 1,4-dioxane; methanol; N,N-dimethyl-formamide; acetone; acetonitrile;
DOI:10.1002/chem.201103833