4a,9b-trans-8-fluoro-5-(4-fluorophenyl)-2-<2-(3-hydroxy-2-phenylpropionamido)ethyl>-1,2,3,4,4a,9b-trans-hexahydro-γ-carboline

Base Information

Chemical Name:4a,9b-trans-8-fluoro-5-(4-fluorophenyl)-2-<2-(3-hydroxy-2-phenylpropionamido)ethyl>-1,2,3,4,4a,9b-trans-hexahydro-γ-carboline
CAS No.:98651-77-5
Molecular Formula:C₂₈H₂₉F₂N₃O₂
Molecular Weight:477.554
Hs Code.:

Synonyms:4a,9b-trans-8-fluoro-5-(4-fluorophenyl)-2-<2-(3-hydroxy-2-phenylpropionamido)ethyl>-1,2,3,4,4a,9b-trans-hexahydro-γ-carboline

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Chemical Property of 4a,9b-trans-8-fluoro-5-(4-fluorophenyl)-2-<2-(3-hydroxy-2-phenylpropionamido)ethyl>-1,2,3,4,4a,9b-trans-hexahydro-γ-carboline

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Technology Process of 4a,9b-trans-8-fluoro-5-(4-fluorophenyl)-2-<2-(3-hydroxy-2-phenylpropionamido)ethyl>-1,2,3,4,4a,9b-trans-hexahydro-γ-carboline

There total 3 articles about 4a,9b-trans-8-fluoro-5-(4-fluorophenyl)-2-<2-(3-hydroxy-2-phenylpropionamido)ethyl>-1,2,3,4,4a,9b-trans-hexahydro-γ-carboline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 529-64-6,28845-94-5
Tropic acid

: 98651-81-1
2-[(4aR,9bR)-8-Fluoro-5-(4-fluoro-phenyl)-1,3,4,4a,5,9b-hexahydro-pyrido[4,3-b]indol-2-yl]-ethylamine

: 98651-77-5
4a,9b-trans-8-fluoro-5-(4-fluorophenyl)-2-<2-(3-hydroxy-2-phenylpropionamido)ethyl>-1,2,3,4,4a,9b-trans-hexahydro-γ-carboline

Guidance literature:: With dicyclohexyl-carbodiimide; In dichloromethane; 1.) 0 deg C, 1 h, 2.) RT, overnight;
DOI:10.1021/jm00151a002

Reference yield:

: 98634-61-8
[(4aR,9bR)-8-Fluoro-5-(4-fluoro-phenyl)-1,3,4,4a,5,9b-hexahydro-pyrido[4,3-b]indol-2-yl]-acetonitrile

: 98651-77-5
4a,9b-trans-8-fluoro-5-(4-fluorophenyl)-2-<2-(3-hydroxy-2-phenylpropionamido)ethyl>-1,2,3,4,4a,9b-trans-hexahydro-γ-carboline

Guidance literature:: Multi-step reaction with 2 steps

1: LiAlH₄ / diethyl ether / 1.5 h

2: 60 percent / 1,3-dicyclohexylcarbodiimide / CH₂Cl₂ / 1.) 0 deg C, 1 h, 2.) RT, overnight

With lithium aluminium tetrahydride; dicyclohexyl-carbodiimide; In diethyl ether; dichloromethane;
DOI:10.1021/jm00151a002

Reference yield:

: 69623-07-0
(+/-)-4a,9b-trans-8-fluoro-5-(4-fluorophenyl)-2,3,4,4a,5,9a-hexahydro-1H-pyrido<4,3-b>indole

: 98651-77-5
4a,9b-trans-8-fluoro-5-(4-fluorophenyl)-2-<2-(3-hydroxy-2-phenylpropionamido)ethyl>-1,2,3,4,4a,9b-trans-hexahydro-γ-carboline

Guidance literature:: Multi-step reaction with 3 steps

1: 71 percent / Na₂CO₃, KI / various solvent(s) / 1.) from 80 deg C to 90 deg C, 18 h, 2.) from 120 deg C to 130 deg C, 72 h

2: LiAlH₄ / diethyl ether / 1.5 h

3: 60 percent / 1,3-dicyclohexylcarbodiimide / CH₂Cl₂ / 1.) 0 deg C, 1 h, 2.) RT, overnight

With lithium aluminium tetrahydride; sodium carbonate; dicyclohexyl-carbodiimide; potassium iodide; In diethyl ether; dichloromethane;
DOI:10.1021/jm00151a002