C₂₈H₅₄O₃Si₂

Base Information

Chemical Name:C₂₈H₅₄O₃Si₂
CAS No.:1312136-54-1
Molecular Formula:C₂₈H₅₄O₃Si₂
Molecular Weight:494.906
Hs Code.:

C<sub>28</sub>H<sub>54</sub>O<sub>3</sub>Si<sub>2</sub>

Synonyms:C₂₈H₅₄O₃Si₂

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Chemical Property of C₂₈H₅₄O₃Si₂

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Technology Process of C₂₈H₅₄O₃Si₂

There total 19 articles about C₂₈H₅₄O₃Si₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1312136-13-2
(4R,6R,8R)-9-(benzyloxy)-4,8-dimethyl-6-(tert-butyldimethylsilyloxy)nonan-3-one

: 1822-00-0
trimethylsilylmethyllithium

: 1312136-54-1
C₂₈H₅₄O₃Si₂

Guidance literature:: (4R,6R,8R)-9-(benzyloxy)-4,8-dimethyl-6-(tert-butyldimethylsilyloxy)nonan-3-one; trimethylsilylmethyllithium; In tetrahydrofuran; pentane; at -78 ℃; for 0.333333h; Inert atmosphere;

With ammonium chloride; In tetrahydrofuran; water; pentane; Inert atmosphere;
DOI:10.3390/molecules16075422

Reference yield:

: 322474-61-3
C₉H₁₆O₄

: 1312136-54-1
C₂₈H₅₄O₃Si₂

Guidance literature:: Multi-step reaction with 18 steps

1.1: lithium hydroxide / tetrahydrofuran; water / 3 h / 0 °C / Inert atmosphere

1.2: pH 4 / Inert atmosphere

2.1: pivaloyl chloride; triethylamine / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere

2.2: 20 °C / Inert atmosphere

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 1.5 h / -40 °C / Inert atmosphere

3.2: 4 h / -20 °C / Inert atmosphere

4.1: lithium borohydride / tetrahydrofuran; methanol; water / 2.5 h / 0 - 20 °C / Inert atmosphere

4.2: 0 °C / Inert atmosphere

5.1: tetra-(n-butyl)ammonium iodide; sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

6.1: water; toluene-4-sulfonic acid / N,N-dimethyl-formamide / 3 h / 0 - 30 °C / 80 Torr

7.1: pyridine / dichloromethane / 1.5 h / 0 - 20 °C / Inert atmosphere

8.1: 1H-imidazole / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

9.1: diisobutylaluminium hydride / hexane; dichloromethane / 1 h / -78 °C / Inert atmosphere

9.2: Inert atmosphere

10.1: sulfur trioxide pyridine complex; dimethyl sulfoxide; triethylamine / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

11.1: N-ethyl-N,N-diisopropylamine; lithium chloride / acetonitrile / 20 °C / Inert atmosphere

12.1: Rh/Al₂O₃; hydrogen / ethyl acetate / 2 h / 20 °C

13.1: lithium hexamethyldisilazane / tetrahydrofuran / 2 h / -40 °C / Inert atmosphere

13.2: 0.5 h / -20 °C / Inert atmosphere

14.1: lithium borohydride / tetrahydrofuran; methanol; water / 1 h / 0 - 20 °C / Inert atmosphere

14.2: 0 °C / Inert atmosphere

15.1: sulfur trioxide pyridine complex; dimethyl sulfoxide; triethylamine / dichloromethane / 1.5 h / 0 - 20 °C / Inert atmosphere

16.1: tetrahydrofuran / 0 °C / Inert atmosphere

16.2: Inert atmosphere

17.1: sulfur trioxide pyridine complex; dimethyl sulfoxide; triethylamine / dichloromethane / 4 h / 0 °C / Inert atmosphere

18.1: tetrahydrofuran; pentane / 0.33 h / -78 °C / Inert atmosphere

18.2: Inert atmosphere

With pyridine; 1H-imidazole; lithium borohydride; Rh/Al₂O₃; water; hydrogen; sulfur trioxide pyridine complex; pivaloyl chloride; tetra-(n-butyl)ammonium iodide; sodium hydride; diisobutylaluminium hydride; toluene-4-sulfonic acid; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine; lithium chloride; lithium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; hexane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; pentane; 3.1: Evans asymmetric alkylation / 10.1: Parikh-Doering oxidation / 11.1: Horner-Wadsworth-Emmons olefination / 13.1: Evans asymmetric alkylation / 15.1: Parikh-Doering oxidation / 16.1: Grignard reaction / 17.1: Parikh-Doering oxidation;
DOI:10.3390/molecules16075422

Reference yield:

: 1312136-34-7
(R)-4-benzyl-3-(3-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-propanoyl)oxazolidin-2-one

: 1312136-54-1
C₂₈H₅₄O₃Si₂

Guidance literature:: Multi-step reaction with 16 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1.5 h / -40 °C / Inert atmosphere

1.2: 4 h / -20 °C / Inert atmosphere

2.1: lithium borohydride / tetrahydrofuran; methanol; water / 2.5 h / 0 - 20 °C / Inert atmosphere

2.2: 0 °C / Inert atmosphere

3.1: tetra-(n-butyl)ammonium iodide; sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

4.1: water; toluene-4-sulfonic acid / N,N-dimethyl-formamide / 3 h / 0 - 30 °C / 80 Torr

5.1: pyridine / dichloromethane / 1.5 h / 0 - 20 °C / Inert atmosphere

6.1: 1H-imidazole / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

7.1: diisobutylaluminium hydride / hexane; dichloromethane / 1 h / -78 °C / Inert atmosphere

7.2: Inert atmosphere

8.1: sulfur trioxide pyridine complex; dimethyl sulfoxide; triethylamine / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

9.1: N-ethyl-N,N-diisopropylamine; lithium chloride / acetonitrile / 20 °C / Inert atmosphere

10.1: Rh/Al₂O₃; hydrogen / ethyl acetate / 2 h / 20 °C

11.1: lithium hexamethyldisilazane / tetrahydrofuran / 2 h / -40 °C / Inert atmosphere

11.2: 0.5 h / -20 °C / Inert atmosphere

12.1: lithium borohydride / tetrahydrofuran; methanol; water / 1 h / 0 - 20 °C / Inert atmosphere

12.2: 0 °C / Inert atmosphere

13.1: sulfur trioxide pyridine complex; dimethyl sulfoxide; triethylamine / dichloromethane / 1.5 h / 0 - 20 °C / Inert atmosphere

14.1: tetrahydrofuran / 0 °C / Inert atmosphere

14.2: Inert atmosphere

15.1: sulfur trioxide pyridine complex; dimethyl sulfoxide; triethylamine / dichloromethane / 4 h / 0 °C / Inert atmosphere

16.1: tetrahydrofuran; pentane / 0.33 h / -78 °C / Inert atmosphere

16.2: Inert atmosphere

With pyridine; 1H-imidazole; lithium borohydride; Rh/Al₂O₃; water; hydrogen; sulfur trioxide pyridine complex; tetra-(n-butyl)ammonium iodide; sodium hydride; diisobutylaluminium hydride; toluene-4-sulfonic acid; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine; lithium chloride; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; hexane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; pentane; 1.1: Evans asymmetric alkylation / 8.1: Parikh-Doering oxidation / 9.1: Horner-Wadsworth-Emmons olefination / 11.1: Evans asymmetric alkylation / 13.1: Parikh-Doering oxidation / 14.1: Grignard reaction / 15.1: Parikh-Doering oxidation;
DOI:10.3390/molecules16075422