1-[4-(4-Methoxyphenoxy)phenyl]ethan-1-one

Base Information

• Chemical Name: 1-[4-(4-Methoxyphenoxy)phenyl]ethan-1-one
• CAS No.: 54916-28-8
• Molecular Formula: C15H14 O3
• Molecular Weight: 242.274
• Hs Code.: 2914509090
• DSSTox Substance ID: DTXSID20380437
• Nikkaji Number: J2.124.009E
• Wikidata: Q82170667
• Mol file: 54916-28-8.mol

Synonyms:54916-28-8;1-(4-(4-Methoxyphenoxy)phenyl)ethanone;1-[4-(4-Methoxyphenoxy)phenyl]ethan-1-one;1-[4-(4-methoxyphenoxy)phenyl]ethanone;4-Acetyl-4'-methoxydiphenyl ether;4'-(4-Methoxyphenoxy)acetophenone;1-[4-(4-Methoxyphenoxy)phenyl]-ethanone;xenytropiumbromide;Maybridge1_003245;SCHEMBL755167;HMS550L11;4-(4-methoxyphenoxy)acetophenone;DTXSID20380437;ICXPZMQQZWKKMN-UHFFFAOYSA-N;MFCD00052928;AKOS000219964;PS-4325;AC-18582;1-[4-(4-methoxy-phenoxy)-phenyl]-ethanone;CS-0186246;FT-0617398;M2740;A50609;A830406

Chemical Property of 1-[4-(4-Methoxyphenoxy)phenyl]ethan-1-one

Chemical Property:

• Melting Point: 56-58°C
• Boiling Point: 198-201°C 2mm
• Flash Point: 198-201°C/2mm
• PSA: 35.53000
• Density: 1.123±0.06 g/cm3(Predicted)
• LogP: 3.69010
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 3.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 242.094294304
• Heavy Atom Count: 18
• Complexity: 261

Purity/Quality:

98%,99%, ^*data from raw suppliers

4''-(4-Methoxyphenoxy)acetophenone ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)C1=CC=C(C=C1)OC2=CC=C(C=C2)OC

Technology Process of 1-[4-(4-Methoxyphenoxy)phenyl]ethan-1-one

There total 17 articles about 1-[4-(4-Methoxyphenoxy)phenyl]ethan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

para-bromoacetophenone (99-90-1) + 4-methoxy-phenol (150-76-5) → 1-[4-(4-methoxyphenoxy)phenyl]ethanone (54916-28-8)

Guidance literature:

With N¹,N²-bis(thiophen-2-ylmethyl)oxalamide; caesium carbonate; sodium L-ascorbate; copper(l) chloride; In 1,4-dioxane; at 80 ℃; Glovebox; Schlenk technique; Sealed tube; Inert atmosphere;

DOI:10.1002/cctc.201900393

Reference yield: 95.0%

para-chloroacetophenone (99-91-2) + 4-methoxy-phenol (150-76-5) → 1-[4-(4-methoxyphenoxy)phenyl]ethanone (54916-28-8)

Guidance literature:

4-methoxy-phenol; With sodium hydride; In toluene; at 100 ℃; for 0.5h;

para-chloroacetophenone; With 1-(2-methoxyethyl)-3-(2,3,4,5,6-pentamethylbenzyl)imidazolinium bromide; palladium diacetate; at 100 ℃; for 2h;

DOI:10.1055/s-2008-1078548

Reference yield: 93.0%

4-Iodoacetophenone (13329-40-3) + 4-methoxy-phenol (150-76-5) → 1-[4-(4-methoxyphenoxy)phenyl]ethanone (54916-28-8)

Guidance literature:

With 1,1,1,5,5,5-hexafluoroacetylacetone; copper(II) ferrite; caesium carbonate; In 1-methyl-pyrrolidin-2-one; at 135 ℃; for 24h; Inert atmosphere; Schlenk technique;

DOI:10.1002/adsc.201200600

upstream raw materials:

1-methoxy-4-phenoxy-benzene

acetyl chloride

1-(4-fluorophenyl)ethanone

4-methoxy-phenol

Downstream raw materials:

3-Dimethylamino-2-dimethylaminomethyl-1-[4-(4-methoxy-phenoxy)-phenyl]-propan-1-one; hydrochloride

4-methoxyphenyl 4-(hydroxyisopropyl)phenyl ether

4-methoxyphenyl 4-(chloroisopropyl)phenyl ether

2-(4-(4-methoxyphenoxy)phenyl)-2-oxoacetic acid

Refernces

• 1、 -. "Novel EDA transient electron donor-acceptor complex, and preparation method and applications thereof". Paragraph 0053-0056. . Retrieved 2019/07/04.
• 2、 -. "EDA (electronic design automation) transient electron donor-acceptor complex as well as preparation method and application thereof". Paragraph 0047-0050. . Retrieved 2019/09/13.