(Z)-N-[(1S)-2-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-1-[[4-[[(1,1-dimethylethyl)diphenylsilyl]oxy]phenyl]methyl]ethyl]-12-hydroxy-9-dodecenamide

Base Information

Chemical Name:(Z)-N-[(1S)-2-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-1-[[4-[[(1,1-dimethylethyl)diphenylsilyl]oxy]phenyl]methyl]ethyl]-12-hydroxy-9-dodecenamide
CAS No.:863544-74-5
Molecular Formula:C₅₃H₆₉NO₄Si₂
Molecular Weight:840.306
Hs Code.:

Synonyms:(Z)-N-[(1S)-2-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-1-[[4-[[(1,1-dimethylethyl)diphenylsilyl]oxy]phenyl]methyl]ethyl]-12-hydroxy-9-dodecenamide

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Chemical Property of (Z)-N-[(1S)-2-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-1-[[4-[[(1,1-dimethylethyl)diphenylsilyl]oxy]phenyl]methyl]ethyl]-12-hydroxy-9-dodecenamide

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Technology Process of (Z)-N-[(1S)-2-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-1-[[4-[[(1,1-dimethylethyl)diphenylsilyl]oxy]phenyl]methyl]ethyl]-12-hydroxy-9-dodecenamide

There total 9 articles about (Z)-N-[(1S)-2-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-1-[[4-[[(1,1-dimethylethyl)diphenylsilyl]oxy]phenyl]methyl]ethyl]-12-hydroxy-9-dodecenamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 863544-73-4
(Z)-N-[(1S)-2-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-1-[[4-[[(1,1-dimethylethyl)diphenylsilyl]oxy]phenyl]methyl]ethyl]-12-[(tetrahydro-2H-pyran-2-yl)oxy]-9-dodecenamide

: 863544-74-5
(Z)-N-[(1S)-2-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-1-[[4-[[(1,1-dimethylethyl)diphenylsilyl]oxy]phenyl]methyl]ethyl]-12-hydroxy-9-dodecenamide

Guidance literature:: With methanol; toluene-4-sulfonic acid; at 25 ℃; for 2.5h;
DOI:10.1021/jm051226l

Reference yield:

: 885022-89-9
di-O-tert-butyldiphenylsilyl-(S)-tyrosinol

: 863544-74-5
(Z)-N-[(1S)-2-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-1-[[4-[[(1,1-dimethylethyl)diphenylsilyl]oxy]phenyl]methyl]ethyl]-12-hydroxy-9-dodecenamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: isobutyl chloroformate; N-methylmorpholine / acetonitrile / 1 h / -5 °C

1.2: 491 mg / acetonitrile / 1 h / 20 °C

2.1: 51 percent / p-toluenesulfonic acid hydrate; MeOH / 2.5 h / 25 °C

With 4-methyl-morpholine; methanol; toluene-4-sulfonic acid; isobutyl chloroformate; In acetonitrile;
DOI:10.1021/jm051226l

Reference yield:

: 34957-73-8
methyl 9-hydroxynonanoate

: 863544-74-5
(Z)-N-[(1S)-2-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-1-[[4-[[(1,1-dimethylethyl)diphenylsilyl]oxy]phenyl]methyl]ethyl]-12-hydroxy-9-dodecenamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: (COCl)2; DMSO; Et₃N

2.1: KHMDS / tetrahydrofuran / -78 °C

3.1: aq. LiOH / tetrahydrofuran

4.1: isobutyl chloroformate; N-methylmorpholine / acetonitrile / 1 h / -5 °C

4.2: 491 mg / acetonitrile / 1 h / 20 °C

5.1: 51 percent / p-toluenesulfonic acid hydrate; MeOH / 2.5 h / 25 °C

With 4-methyl-morpholine; methanol; lithium hydroxide; oxalyl dichloride; potassium hexamethylsilazane; toluene-4-sulfonic acid; dimethyl sulfoxide; triethylamine; isobutyl chloroformate; In tetrahydrofuran; acetonitrile; 1.1: Swern oxidation / 2.1: Wittig olefination;
DOI:10.1021/jm051226l