methyl (-)-(1S,2R)-2-[(1-adamantylamino)methyl]-1-phenylcyclopropanecarboxylate

Base Information

Chemical Name:methyl (-)-(1S,2R)-2-[(1-adamantylamino)methyl]-1-phenylcyclopropanecarboxylate
CAS No.:290342-18-6
Molecular Formula:C₂₂H₂₉NO₂
Molecular Weight:339.478
Hs Code.:

Synonyms:methyl (-)-(1S,2R)-2-[(1-adamantylamino)methyl]-1-phenylcyclopropanecarboxylate

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Chemical Property of methyl (-)-(1S,2R)-2-[(1-adamantylamino)methyl]-1-phenylcyclopropanecarboxylate

Chemical Property:

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Technology Process of methyl (-)-(1S,2R)-2-[(1-adamantylamino)methyl]-1-phenylcyclopropanecarboxylate

There total 3 articles about methyl (-)-(1S,2R)-2-[(1-adamantylamino)methyl]-1-phenylcyclopropanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 768-94-5
1-Adamantanamine

: 290341-76-3
methyl (-)-(1S,2R)-2-(bromomethyl)-1-phenylcyclopropanecarboxylate

: 290342-18-6
methyl (-)-(1S,2R)-2-[(1-adamantylamino)methyl]-1-phenylcyclopropanecarboxylate

Guidance literature:: With sodium hydrogencarbonate; In N,N-dimethyl-formamide; at 70 ℃; for 8h;
DOI:10.1016/S0968-0896(00)00072-9

Reference yield:

: 69160-63-0
(1S,2R)-2-(bromomethyl)-1-phenylcyclopropanecarboxylic acid

: 290342-18-6
methyl (-)-(1S,2R)-2-[(1-adamantylamino)methyl]-1-phenylcyclopropanecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: SOCl₂ / benzene / 5 h / Heating

2: HCl / benzene / 5 h / 20 °C

3: NaHCO₃ / dimethylformamide / 8 h / 70 °C

With hydrogenchloride; thionyl chloride; sodium hydrogencarbonate; In N,N-dimethyl-formamide; benzene;
DOI:10.1016/S0014-827X(01)01170-3

Reference yield:

: (1S,2R)-2-(bromomethyl)-1-phenylcyclopropanecarboxylic acid chloride

: 290342-18-6
methyl (-)-(1S,2R)-2-[(1-adamantylamino)methyl]-1-phenylcyclopropanecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: HCl / benzene / 5 h / 20 °C

2: NaHCO₃ / dimethylformamide / 8 h / 70 °C

With hydrogenchloride; sodium hydrogencarbonate; In N,N-dimethyl-formamide; benzene;
DOI:10.1016/S0014-827X(01)01170-3