Methyl 4-methoxythiophene-3-carboxylate

Base Information

• Chemical Name: Methyl 4-methoxythiophene-3-carboxylate
• CAS No.: 65369-22-4
• Molecular Formula: C₇H₈O₃S
• Molecular Weight: 172.205
• Hs Code.: 2934999090
• DSSTox Substance ID: DTXSID50380889
• Wikidata: Q72486209

Synonyms:methyl 4-methoxythiophene-3-carboxylate;65369-22-4;4-methoxy-thiophene-3-carboxylic acid methyl ester;3-Thiophenecarboxylic acid, 4-methoxy-, methyl ester;Methyl 4-Methoxythiophene-3-arboxylate;4-methoxy-3-thiophenecarboxylic acid methyl ester;methyl 4-methoxy-3-thiophenecarboxylate;Maybridge1_004625;SCHEMBL6766241;HMS554K05;DTXSID50380889;CHEBI:194907;LQIVVUILGDRRHE-UHFFFAOYSA-N;MFCD00067995;AKOS006228817;methyl4-methoxythiophene-3-carboxylate;AS-5690;CS-0312822;FT-0628650;D95808;3-methoxythiophene-4-carboxylic acid methyl ester;3-Thiophenecarboxylicacid,4-methoxy-,methyl ester;A835092;J-522370

Chemical Property of Methyl 4-methoxythiophene-3-carboxylate

Chemical Property:

• Vapor Pressure: 0.0247mmHg at 25°C
• Melting Point: 70 °C
• Boiling Point: 248.1°C at 760 mmHg
• Flash Point: 103.9°C
• PSA: 63.77000
• Density: 1.222g/cm³
• LogP: 1.54330
• Storage Temp.: 2-8°C
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 172.01941529
• Heavy Atom Count: 11
• Complexity: 149

Purity/Quality:

98%min ^*data from raw suppliers

Methyl 4-methoxythiophene-3-carboxylate ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36/37/39-24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CSC=C1C(=O)OC

Technology Process of Methyl 4-methoxythiophene-3-carboxylate

There total 5 articles about Methyl 4-methoxythiophene-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

methyl 2,5-dihydro-4-methoxythiophene-3-carboxylate (22097-91-2) → methyl 4-methoxy-3-thiophenecarboxylate (65369-22-4)

Guidance literature:

With sulfuryl dichloride; In dichloromethane; for 1.5h;

DOI:10.1021/jo01292a012

Reference yield: 83.0%

diazomethane (186581-53-3,908094-01-9,334-88-3) + 4-bromo-3-thiophenecarboxylic acid methyl ester (78071-37-1) + sodium methylate (124-41-4) → methyl 4-methoxy-3-thiophenecarboxylate (65369-22-4)

Guidance literature:

4-bromo-3-thiophenecarboxylic acid methyl ester; sodium methylate; With sodium iodide; copper(II) oxide; In methanol; for 68h; Heating;

diazomethane; In diethyl ether; at 0 ℃;

DOI:10.1021/jm0205189

Reference yield:

3-methoxy-dihydrothiophene-4-carboxylic acid methyl ester → methyl 4-methoxy-3-thiophenecarboxylate (65369-22-4)

Guidance literature:

With chlorine; In tetrachloromethane;

upstream raw materials:

methyl 2,5-dihydro-4-methoxythiophene-3-carboxylate

diazomethane

4-bromo-3-thiophenecarboxylic acid methyl ester

sodium methylate

Downstream raw materials:

4-methoxythiophene-3-carbohydrazide

4-methoxy-3-thiophenecarboxylic acid

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