(S)-Cyclohexyl-[2-(3-hydroxy-phenyl)-acetylamino]-acetic acid methyl ester

Base Information

Chemical Name:(S)-Cyclohexyl-[2-(3-hydroxy-phenyl)-acetylamino]-acetic acid methyl ester
CAS No.:426825-52-7
Molecular Formula:C₁₇H₂₃NO₄
Molecular Weight:305.374
Hs Code.:

Synonyms:(S)-Cyclohexyl-[2-(3-hydroxy-phenyl)-acetylamino]-acetic acid methyl ester

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Chemical Property of (S)-Cyclohexyl-[2-(3-hydroxy-phenyl)-acetylamino]-acetic acid methyl ester

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Technology Process of (S)-Cyclohexyl-[2-(3-hydroxy-phenyl)-acetylamino]-acetic acid methyl ester

There total 1 articles about (S)-Cyclohexyl-[2-(3-hydroxy-phenyl)-acetylamino]-acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 621-37-4
m-hydroxyphenylacetic acid

: 14328-63-3,14328-64-4
methyl (2S)-amino(cyclohexyl)ethanoate hydrochloride

: 426825-52-7
(S)-Cyclohexyl-[2-(3-hydroxy-phenyl)-acetylamino]-acetic acid methyl ester

Guidance literature:: With 4-methyl-morpholine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3-hydroxy-3,4-dihydrobenzotriazine-4-one; In dichloromethane; N,N-dimethyl-formamide; at -20 - 20 ℃;
DOI:10.1021/jo020075g

Reference yield:

: 426825-52-7
(S)-Cyclohexyl-[2-(3-hydroxy-phenyl)-acetylamino]-acetic acid methyl ester

: 426825-49-2
(S)-Cyclohexyl-[2-(3-hydroxy-phenyl)-acetylamino]-acetic acid

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; methanol; water; at -10 ℃; for 4h;
DOI:10.1021/jo020075g

Reference yield:

: 426825-52-7
(S)-Cyclohexyl-[2-(3-hydroxy-phenyl)-acetylamino]-acetic acid methyl ester

: methyl 8(R),13(S)-13-cyclohexyl-6,6-dimethyl-12,15-dioxo-2,7-dioxa-11,14-diazatricyclo[15.3.1.1(8,11)]docosa-1⁽²¹⁾,17,19-triene-10(S)-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: LiOH / methanol; tetrahydrofuran; H₂O / 4 h / -10 °C

2: 3.56 g / 3-hydroxy-1,2,3-benzotriazin-4(3H)-one; 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride; 4-methylmorpholine / dimethylformamide; CH₂Cl₂ / -20 - 20 °C

3: 10 percent / 1,1'-(azodicarbonyl)dipiperidine; triphenylphosphine / CH₂Cl₂

With 4-methyl-morpholine; lithium hydroxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3-hydroxy-3,4-dihydrobenzotriazine-4-one; triphenylphosphine; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; 3: Mitsunobu reaction;
DOI:10.1021/jo020075g