10-benzyl-2-phenyl-3a,4,9,9a-tetrahydro-1H-4,9-epiminobenzo[f]isoindole-1,3(2H)-dione

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Chemical Name:10-benzyl-2-phenyl-3a,4,9,9a-tetrahydro-1H-4,9-epiminobenzo[f]isoindole-1,3(2H)-dione
CAS No.:123542-36-9
Molecular Formula:C₂₅H₂₀N₂O₂
Molecular Weight:380.446
Hs Code.:

Synonyms:10-benzyl-2-phenyl-3a,4,9,9a-tetrahydro-1H-4,9-epiminobenzo[f]isoindole-1,3(2H)-dione

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Chemical Property of 10-benzyl-2-phenyl-3a,4,9,9a-tetrahydro-1H-4,9-epiminobenzo[f]isoindole-1,3(2H)-dione

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Technology Process of 10-benzyl-2-phenyl-3a,4,9,9a-tetrahydro-1H-4,9-epiminobenzo[f]isoindole-1,3(2H)-dione

There total 4 articles about 10-benzyl-2-phenyl-3a,4,9,9a-tetrahydro-1H-4,9-epiminobenzo[f]isoindole-1,3(2H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 941-69-5
N-phenyl-maleimide

: 25473-60-3
2-benzyl-2H-isoindole

: 123542-36-9
10-benzyl-2-phenyl-3a,4,9,9a-tetrahydro-1H-4,9-epiminobenzo[f]isoindole-1,3(2H)-dione

Guidance literature:: In dichloromethane; at 0 ℃; for 1h; Inert atmosphere; Schlenk technique;
DOI:10.1021/acs.orglett.7b02739

Reference yield:

: 2142-01-0
N-benzylphthalimide

: 123542-36-9
10-benzyl-2-phenyl-3a,4,9,9a-tetrahydro-1H-4,9-epiminobenzo[f]isoindole-1,3(2H)-dione

Guidance literature:: Multi-step reaction with 2 steps

1: 31 percent / LiAlH₄; methanol / tetrahydrofuran / 1 h / -40 - 0 °C

2: 81 percent / CH₂Cl₂ / 0.83 h / 0 °C

With methanol; lithium aluminium tetrahydride; In tetrahydrofuran; dichloromethane; 2: Diels-Alder reaction;
DOI:10.1021/ja010917d

Reference yield:

: 13380-32-0
2-benzylisoindolin-1-one

: 123542-36-9
10-benzyl-2-phenyl-3a,4,9,9a-tetrahydro-1H-4,9-epiminobenzo[f]isoindole-1,3(2H)-dione

Guidance literature:: Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / tetrahydrofuran; methanol / -78 - 25 °C / Inert atmosphere; Schlenk technique

2: dichloromethane / 1 h / 0 °C / Inert atmosphere; Schlenk technique

With lithium aluminium tetrahydride; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/acs.orglett.7b02739