25473-60-3

Usage

Isoindole moiety

cyclohexa-2,4-dien-1-one linked to a benzene ring
Commonly used as a building block in the synthesis of pharmaceuticals, dyes, and fragrances
Known for its antioxidant properties and used in the production of antioxidants

Physical form

colorless, crystalline solid

Solubility

insoluble in water, soluble in organic solvents such as ethanol and ether

Potential hazards

may cause irritation to the skin and eyes upon contact

Upstream product

• 2142-01-0 N-benzylphthalimide 
• 108683-62-1 2-(chloromethyl)benzaldehyde 
• 100-46-9 benzylamine 
• 13380-32-0 2-benzylisoindolin-1-one 
• 85-44-9 phthalic anhydride 
• 60633-91-2 2-(bromomethyl)benzaldehyde 

Downstream Products

• 25473-61-4 9-benzyl-1,2,3,4-tetrahydro-1,4-epiazano-naphthalene-2,3-dicarboxylic acid anhydride 
• 113859-53-3 7-benzyl-2,3:5,6-dibenzo-7-azabicyclo<2.2.1>hepta-2,5-diene 
• 86557-81-5 endo-4,9-benzylepimino-3a,9a-dihydro-2-methyl-1,3-dioxobenz-isoindoline 
• 123542-36-9 10-benzyl-2-phenyl-3a,4,9,9a-tetrahydro-1H-4,9-epiminobenzo[f]isoindole-1,3(2H)-dione 
• 378245-74-0 N-benzyl-7-azabenzobicyclo[2.2.1]heptene-2,3-dicarboxylic anhydride 
• 1123175-97-2 N-benzyl-1-methyl-9,10-dihydroanthracene-9,10-imine hydrochloride 
• 1123175-96-1 N-benzyl-1-methyl-9,10-dihydroanthracene-9,10-imine 
• 1319163-43-3 C₂₄H₂₄N₂O₄ 
• 1319163-48-8 C₂₀H₁₈N₂O₂ 
• 120-12-7 anthracene 
• 905440-71-3 9-benzyl-2,3-bis-trifluoromethyl-1,2,3,4-tetrahydro-1,4-epiazano-naphthalene 
• 927203-44-9 9-benzyl-1,2,3,4-tetrahydro-1,4-epiazano-naphthalene-2,3-dicarboxylic acid dimethyl ester 

Relevant academic research and scientific papers

Tri(pentaflurophenyl)borane-catalyzed reduction of cyclic imides with hydrosilanes: Synthesis of pyrrolidines

B(C6F5)3-catalyzed hydrosilylation of cyclic imides afforded an efficient synthetic method of pyrrolidines. In the presence of 5 mol% B(C6F5)3, various aromatic, aliphatic and polycyclic imides were smoothly reduced by PhSiH3 to generate the corresponding pyrrolidines in high yields. The reaction profiles monitored by 1H NMR spectroscopy disclosed the reduction process of cyclic imides and the effect of difference structure of the hydrosilanes on the hydrosilylation.

A kind of benzo 7 bit azabicyclo rhodamine dye (by machine translation)

The invention discloses a benzo 7 bit azabicyclo rhodamine dye, its structural general formula is: Wherein X=O, Si, Se, R2 =CO2 - , SO3 - . The dye has excellent optical properties, for example has high light stability, high molar extinction coefficient, relatively high quantum yield or the like. In the fluorescent probe, fluorescent labeling, the photodynamic therapy, such as the catch system and laser dyes in the field of biotechnology application, and has a wide application. (by machine translation)

Reduction of Benzolactams to Isoindoles via an Alkoxide-Catalyzed Hydrosilylation

An alkoxide-catalyzed reduction of benzolactams to isoindoles with silanes was realized. With t-BuOK as the catalyst and Ph2SiH2 as the reductant, a series of benzolactams containing different functional groups were reduced to the co

New compd. and resistance inducer for plant

PROBLEM TO BE SOLVED: To provide a novel compound and a resistance inducer for a plant using the same.SOLUTION: There are provided a compound represented by the general formula (1), where Xis a group represented by the general formula (1a) or (1b), Zis a monovalent group other than a hydrogen atom, Zis an electron-withdrawing group, Rand Rare a hydrogen atom and the like, m is an integer of 0 to 4, a plurality of Zmay be same or different each other when m is 2 to 4, Ris a hydrocarbon group which may have a substituent, and a resistance inducer for a plant containing the compound as an active ingredient.

COMPOUND, ORGANIC OPTOELECTRIC DEVICE AND DISPLAY DEVICE

Provided is a compound providing an organic optoelectric device having properties such as high efficiency and long life. The present invention relates to a compound represented by chemical formula 1, an organic optoelectric device including the same, and

Resistance inducer for plant

PROBLEM TO BE SOLVED: To provide a resistance inducing agent for a plant having a new chemical structure. SOLUTION: This resistance inducing agent for a plant contains a compound represented by general formula (1) as an active ingredient (in the for

Transnitrosylation directs TRPA1 selectivity in n-nitrosamine activators

S-Nitrosylation, the addition of a nitrosyl group to cysteine thiols, regulates various protein functions to mediate nitric oxide (NO) bioactivity. Recent studies have demonstrated that selectivity in protein S-nitrosylation signaling pathways is conferre

Visible-light-triggered release of nitric oxide from N-pyramidal nitrosamines

Although many organic/inorganic compounds that release nitric oxide (NO) upon photoirradiation (phototriggered caged-NOs) have been reported, their photoabsorption wavelengths mostly lie in the UV region, because X - NO bonds (X=heteroatom and metal) generally have rather strong π-bond character. Thus, it is intrinsically difficult to generate organic compounds that release NO under visible light irradiation. Herein, the structures and properties of N-pyramidal nitrosamine derivatives of 7-azabicyclo[2.2.1]heptanes that release NO under visible light irradiation are described. Bathochromic shifts of the absorptions of these nitrosamines, attributed to HOMO (n)-LUMO (π*) transitions associated with the nonplanar structure of the N - NO moiety, enable the molecules to absorb visible light, which results in N - NO bond cleavage. Thus, these compounds are innate organic caged-NOs that are uncaged by visible light. A visible difference: Nitrosamine derivatives of 7-azabicyclo[2.2.1]heptanes undergo N - NO bond cleavage upon exposure to visible light at wavelengths longer than 420a nm, thereby releasing NO. Bathochromic shifts of the absorptions of these nitrosamines are attributed to HOMO (n)-LUMO (π*) transitions associated with the nonplanar structure of the N - NO moiety (see figure). Copyright

2-Substituted-isoindoles: A novel synthetic route and a study of the iels-Alder and Michael reactions

A novel one-step procedure for the synthesis of 2-substituted-isoindoles and 1-aryl-2-substituted-isoindoles is described. The procedure is based on the reaction of 2-(bromomethyl)benzaldehyde or 2-(bromomethyl)benzophenone derivatives with primary aromatic or aliphatic amines. Reactions of 1,2-diarylisoindoles with N-phenylmaleimide were studied. Refluxing the reactants in i-PrOH in the presence of triethylamine leads to the formation of Diels-Alder endo-adducts; whilst refluxing in AcOH in the presence of AcONa affords Michael adducts. The structure of the latter was confirmed by X-ray diffraction.

7-Azabicyclo[2.2.1]heptane as a structural motif to block mutagenicity of nitrosamines

Nitrosamines are potent carcinogens and toxicants in the rat and potential genotoxins in humans. They are metabolically activated by hydroxylation at an α-carbon atom with respect to the nitrosoamino group, catalyzed by cytochrome P450. However, there has been little systematic investigation of the structure-mutagenic activity relationship of N-nitrosamines. Herein, we evaluated the mutagenicity of a series of 7-azabicyclo[2.2.1]heptane N-nitrosamines and related monocyclic nitrosamines by using the Ames assay. Our results show that the N-nitrosamine functionality embedded in the bicyclic 7-azabicylo[2.2.1]heptane structure lacks mutagenicity, that is, it is inert to α-hydroxylation, which is the trigger of mutagenic events. Further, the calculated α-C-H bond dissociation energies of the bicyclic nitrosamines are larger in magnitude than those of the corresponding monocyclic nitrosamines and N-nitrosodimethylamine by as much as 20-30 kcal/mol. These results are consistent with lower α-C-H bond reactivity of the bicyclic nitrosamines. Thus, the 7-azabicyclo[2.2.1]heptane structural motif may be useful for the design of nongenotoxic nitrosamine compounds with potential biological/medicinal applications.