4β-(4-methylpiperazin-1-yl)sulfonamido-4'-tert-butyldimethylsilyloxy-4'-O-demethyl-4-desoxypodophyllotoxin

Base Information

• Chemical Name: 4β-(4-methylpiperazin-1-yl)sulfonamido-4'-tert-butyldimethylsilyloxy-4'-O-demethyl-4-desoxypodophyllotoxin
• CAS No.: 692755-64-9
• Molecular Formula: C₃₂H₄₅N₃O₉SSi
• Molecular Weight: 675.875

Synonyms:4β-(4-methylpiperazin-1-yl)sulfonamido-4'-tert-butyldimethylsilyloxy-4'-O-demethyl-4-desoxypodophyllotoxin

Chemical Property of 4β-(4-methylpiperazin-1-yl)sulfonamido-4'-tert-butyldimethylsilyloxy-4'-O-demethyl-4-desoxypodophyllotoxin

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4β-(4-methylpiperazin-1-yl)sulfonamido-4'-tert-butyldimethylsilyloxy-4'-O-demethyl-4-desoxypodophyllotoxin

There total 3 articles about 4β-(4-methylpiperazin-1-yl)sulfonamido-4'-tert-butyldimethylsilyloxy-4'-O-demethyl-4-desoxypodophyllotoxin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

4-methyl-piperazin-1-ylsulphonyl chloride (1688-95-5) + 4-β-amino-4'-tert-butyldimethylsilyloxy-4'-O-demethyl-4-desoxypodophyllotoxin (692755-45-6) → 4β-(4-methylpiperazin-1-yl)sulfonamido-4'-tert-butyldimethylsilyloxy-4'-O-demethyl-4-desoxypodophyllotoxin (692755-64-9)

Guidance literature:

With 1,4-diaza-bicyclo[2.2.2]octane; In dichloromethane; at 20 ℃; for 30h;

DOI:10.1021/jm031117b

Reference yield:

(5R,5aR,8aS,9S)-9-amino-5-(4-hydroxy-3,5-dimethoxyphenyl)-5,5a,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(8H)-one (117507-84-3) → 4β-(4-methylpiperazin-1-yl)sulfonamido-4'-tert-butyldimethylsilyloxy-4'-O-demethyl-4-desoxypodophyllotoxin (692755-64-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / imidazole / dimethylformamide / 17 h

2: 89 percent / DABCO / CH₂Cl₂ / 30 h / 20 °C

With 1,4-diaza-bicyclo[2.2.2]octane; 1H-imidazole; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm031117b

Reference yield:

tert-butyldimethylsilyl chloride (18162-48-6) → 4β-(4-methylpiperazin-1-yl)sulfonamido-4'-tert-butyldimethylsilyloxy-4'-O-demethyl-4-desoxypodophyllotoxin (692755-64-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / imidazole / dimethylformamide / 17 h

2: 89 percent / DABCO / CH₂Cl₂ / 30 h / 20 °C

With 1,4-diaza-bicyclo[2.2.2]octane; 1H-imidazole; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm031117b

upstream raw materials:

4-methyl-piperazin-1-ylsulphonyl chloride

4-β-amino-4'-tert-butyldimethylsilyloxy-4'-O-demethyl-4-desoxypodophyllotoxin

(5R,5aR,8aS,9S)-9-amino-5-(4-hydroxy-3,5-dimethoxyphenyl)-5,5a,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(8H)-one

tert-butyldimethylsilyl chloride

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 692755-64-9 4β-(4-methylpiperazin-1-yl)sulfonamido-4'-tert-butyldimethylsilyloxy-4'-O-demethyl-4-desoxypodophyllotoxin

Send

Send

Metric Ton KG G Pound L ML

Send

Send