3-(5-bromo-6-ethenyl-2-hydroxy-3-methoxyphenyl)-N-phenyl-2-pyridinecarboxamide

Base Information

Chemical Name:3-(5-bromo-6-ethenyl-2-hydroxy-3-methoxyphenyl)-N-phenyl-2-pyridinecarboxamide
CAS No.:950478-60-1
Molecular Formula:C₂₁H₁₇BrN₂O₃
Molecular Weight:425.282
Hs Code.:

Synonyms:3-(5-bromo-6-ethenyl-2-hydroxy-3-methoxyphenyl)-N-phenyl-2-pyridinecarboxamide

Suppliers and Price of 3-(5-bromo-6-ethenyl-2-hydroxy-3-methoxyphenyl)-N-phenyl-2-pyridinecarboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-(5-bromo-6-ethenyl-2-hydroxy-3-methoxyphenyl)-N-phenyl-2-pyridinecarboxamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-(5-bromo-6-ethenyl-2-hydroxy-3-methoxyphenyl)-N-phenyl-2-pyridinecarboxamide

There total 11 articles about 3-(5-bromo-6-ethenyl-2-hydroxy-3-methoxyphenyl)-N-phenyl-2-pyridinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 950478-59-8
3-(6-ethenyl-2-hydroxy-3-methoxyphenyl)-N-phenyl-2-pyridinecarboxamide

: 950478-60-1
3-(5-bromo-6-ethenyl-2-hydroxy-3-methoxyphenyl)-N-phenyl-2-pyridinecarboxamide

Guidance literature:: With dioxane dibromide; triethylamine; In dichloromethane; at -78 - 20 ℃;
DOI:10.1021/ol0711974

Reference yield:

: 916225-92-8
2-iodo-4-methoxy-3-(methoxymethoxy)benzaldehyde

: 950478-60-1
3-(5-bromo-6-ethenyl-2-hydroxy-3-methoxyphenyl)-N-phenyl-2-pyridinecarboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: 98 percent / molecular sieves 4 Angstroem / CH₂Cl₂ / 6 h / 20 °C

2.1: 1.52 g / copper bronze / Pd(PPh₃)4 / dimethylformamide / 3 h / 100 - 110 °C

3.1: 91 percent / TMSBr / CH₂Cl₂ / 2.92 h / 0 - 20 °C

4.1: potassium t-butoxide / tetrahydrofuran / 1 h / 20 °C

4.2: 88 percent / tetrahydrofuran / 4 h / 55 °C

5.1: 89 percent / Br₂*1,4-dioxane; triethylamine / CH₂Cl₂ / -78 - 20 °C

With trimethylsilyl bromide; 4 A molecular sieve; potassium tert-butylate; dioxane dibromide; copper; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 2.1: Ullmann cross-coupling / 4.2: Wittig reaction;
DOI:10.1021/ol0711974

Reference yield:

: 621-59-0
isovanillin

: 950478-60-1
3-(5-bromo-6-ethenyl-2-hydroxy-3-methoxyphenyl)-N-phenyl-2-pyridinecarboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: ICl; pyridine / CH₂Cl₂ / 96 h / 20 °C

2.1: 28.5 g / NaH / dimethylformamide / 2.25 h / 0 - 20 °C

3.1: 98 percent / molecular sieves 4 Angstroem / CH₂Cl₂ / 6 h / 20 °C

4.1: 1.52 g / copper bronze / Pd(PPh₃)4 / dimethylformamide / 3 h / 100 - 110 °C

5.1: 91 percent / TMSBr / CH₂Cl₂ / 2.92 h / 0 - 20 °C

6.1: potassium t-butoxide / tetrahydrofuran / 1 h / 20 °C

6.2: 88 percent / tetrahydrofuran / 4 h / 55 °C

7.1: 89 percent / Br₂*1,4-dioxane; triethylamine / CH₂Cl₂ / -78 - 20 °C

With pyridine; trimethylsilyl bromide; 4 A molecular sieve; potassium tert-butylate; Iodine monochloride; dioxane dibromide; copper; sodium hydride; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 4.1: Ullmann cross-coupling / 6.2: Wittig reaction;
DOI:10.1021/ol0711974