(E)-tert-butyl 3-(3-(2-benzoylhydrazinyl)-3-oxoprop-1-enyl)-1H-indole-1-carboxylate

Base Information

Chemical Name:(E)-tert-butyl 3-(3-(2-benzoylhydrazinyl)-3-oxoprop-1-enyl)-1H-indole-1-carboxylate
CAS No.:1407499-54-0
Molecular Formula:C₂₃H₂₃N₃O₄
Molecular Weight:405.453
Hs Code.:

Synonyms:(E)-tert-butyl 3-(3-(2-benzoylhydrazinyl)-3-oxoprop-1-enyl)-1H-indole-1-carboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-tert-butyl 3-(3-(2-benzoylhydrazinyl)-3-oxoprop-1-enyl)-1H-indole-1-carboxylate

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Technology Process of (E)-tert-butyl 3-(3-(2-benzoylhydrazinyl)-3-oxoprop-1-enyl)-1H-indole-1-carboxylate

There total 5 articles about (E)-tert-butyl 3-(3-(2-benzoylhydrazinyl)-3-oxoprop-1-enyl)-1H-indole-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.2%

: 613-94-5
benzoic acid hydrazide

: 359700-09-7
(E)-3-(1-(tert-butoxycarbonyl)-1H-indol-3-yl)acrylic acid

: 1407499-54-0
(E)-tert-butyl 3-(3-(2-benzoylhydrazinyl)-3-oxoprop-1-enyl)-1H-indole-1-carboxylate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 12h;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1407499-54-0
(E)-tert-butyl 3-(3-(2-benzoylhydrazinyl)-3-oxoprop-1-enyl)-1H-indole-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / tetrahydrofuran / 60 °C

2: sodium hydroxide; water / tetrahydrofuran; methanol / 12 h / 50 °C

3: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 12 h

With water; potassium carbonate; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; sodium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1002/bkcs.10123

Reference yield:

: 1204-06-4,29953-71-7
trans-3-indole-acrylic acid

: 1407499-54-0
(E)-tert-butyl 3-(3-(2-benzoylhydrazinyl)-3-oxoprop-1-enyl)-1H-indole-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / acetone / 72 h / 60 °C

2: potassium carbonate / tetrahydrofuran / 60 °C

3: sodium hydroxide; water / tetrahydrofuran; methanol / 12 h / 50 °C

4: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 12 h

With water; potassium carbonate; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; sodium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; acetone;
DOI:10.1002/bkcs.10123