(3S,4R)-4-diethoxyphosphinyl-1-(4-methoxyphenyl)-3-<(R)-1-(4-nitrobenzyloxycarbonyloxy)ethyl>-2-azetidinone

Base Information

Chemical Name:(3S,4R)-4-diethoxyphosphinyl-1-(4-methoxyphenyl)-3-<(R)-1-(4-nitrobenzyloxycarbonyloxy)ethyl>-2-azetidinone
CAS No.:93591-37-8
Molecular Formula:C₂₄H₂₉N₂O₁₀P
Molecular Weight:536.475
Hs Code.:

Synonyms:(3S,4R)-4-diethoxyphosphinyl-1-(4-methoxyphenyl)-3-<(R)-1-(4-nitrobenzyloxycarbonyloxy)ethyl>-2-azetidinone

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Chemical Property of (3S,4R)-4-diethoxyphosphinyl-1-(4-methoxyphenyl)-3-<(R)-1-(4-nitrobenzyloxycarbonyloxy)ethyl>-2-azetidinone

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Technology Process of (3S,4R)-4-diethoxyphosphinyl-1-(4-methoxyphenyl)-3-<(R)-1-(4-nitrobenzyloxycarbonyloxy)ethyl>-2-azetidinone

There total 5 articles about (3S,4R)-4-diethoxyphosphinyl-1-(4-methoxyphenyl)-3-<(R)-1-(4-nitrobenzyloxycarbonyloxy)ethyl>-2-azetidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 93591-35-6
(3S,4R)-4-diethoxyphosphinyl-3-<(R)-1-hydroxyethyl>-1-(4-methoxyphenyl)-2-azetidinone

: 4457-32-3
4-nitrobenzyl chloroformate

: 93591-37-8
(3S,4R)-4-diethoxyphosphinyl-1-(4-methoxyphenyl)-3-<(R)-1-(4-nitrobenzyloxycarbonyloxy)ethyl>-2-azetidinone

Guidance literature:: With dmap; In dichloromethane; for 2h; Ambient temperature;
DOI:10.1246/bcsj.60.645

Reference yield:

: 32752-37-7
1,3,5-tris(4-methoxyphenyl)-1,3,5-triazinane

: 93591-37-8
(3S,4R)-4-diethoxyphosphinyl-1-(4-methoxyphenyl)-3-<(R)-1-(4-nitrobenzyloxycarbonyloxy)ethyl>-2-azetidinone

Guidance literature:: Multi-step reaction with 4 steps

1: 61 percent / 6 h / 100 °C

2: 21 percent / DCC / tetrahydrofuran / 0.17 h / Ambient temperature

3: 61 percent / lithium hexamethyldisilazanide / tetrahydrofuran; hexane / 0.5 h / 0 - 5 °C

4: 97 percent / DMAP / CH₂Cl₂ / 2 h / Ambient temperature

With dmap; dicyclohexyl-carbodiimide; lithium hexamethyldisilazane; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1246/bcsj.60.645

Reference yield:

: 81439-58-9
diethyl ester of p-N-methoxyphenylaminomethylphosphonic acid

: 93591-37-8
(3S,4R)-4-diethoxyphosphinyl-1-(4-methoxyphenyl)-3-<(R)-1-(4-nitrobenzyloxycarbonyloxy)ethyl>-2-azetidinone

Guidance literature:: Multi-step reaction with 3 steps

1: 21 percent / DCC / tetrahydrofuran / 0.17 h / Ambient temperature

2: 61 percent / lithium hexamethyldisilazanide / tetrahydrofuran; hexane / 0.5 h / 0 - 5 °C

3: 97 percent / DMAP / CH₂Cl₂ / 2 h / Ambient temperature

With dmap; dicyclohexyl-carbodiimide; lithium hexamethyldisilazane; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1246/bcsj.60.645