N-2-(2-(5-(3,4-dichlorophenyl)furan-2-yl)ethyl)-N-5-(2-hydroxyethyl)-pyrazine-2,5-dicarboxamide

Base Information

Chemical Name:N-2-(2-(5-(3,4-dichlorophenyl)furan-2-yl)ethyl)-N-5-(2-hydroxyethyl)-pyrazine-2,5-dicarboxamide
CAS No.:1297536-61-8
Molecular Formula:C₂₀H₁₈Cl₂N₄O₄
Molecular Weight:449.293
Hs Code.:

Synonyms:N-2-(2-(5-(3,4-dichlorophenyl)furan-2-yl)ethyl)-N-5-(2-hydroxyethyl)-pyrazine-2,5-dicarboxamide

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Chemical Property of N-2-(2-(5-(3,4-dichlorophenyl)furan-2-yl)ethyl)-N-5-(2-hydroxyethyl)-pyrazine-2,5-dicarboxamide

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Technology Process of N-2-(2-(5-(3,4-dichlorophenyl)furan-2-yl)ethyl)-N-5-(2-hydroxyethyl)-pyrazine-2,5-dicarboxamide

There total 4 articles about N-2-(2-(5-(3,4-dichlorophenyl)furan-2-yl)ethyl)-N-5-(2-hydroxyethyl)-pyrazine-2,5-dicarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1297536-57-2
5-(2-(5-(3,4-dichlorophenyl)furan-2-yl)ethylcarbamoyl)pyrazine-2-carboxylic acid

: 141-43-5
ethanolamine

: 1297536-61-8
N-2-(2-(5-(3,4-dichlorophenyl)furan-2-yl)ethyl)-N-5-(2-hydroxyethyl)-pyrazine-2,5-dicarboxamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane;

Reference yield:

: 1297536-44-7
2-(3,4-dichlorophenyl)-5-((E)-2-nitrovinyl)furan

: 1297536-61-8
N-2-(2-(5-(3,4-dichlorophenyl)furan-2-yl)ethyl)-N-5-(2-hydroxyethyl)-pyrazine-2,5-dicarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride; hydrogen / palladium 10% on activated carbon / ethyl acetate; methanol / 4 h / 20 °C / 2280.15 Torr

2: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane

3: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane

With hydrogenchloride; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In methanol; dichloromethane; ethyl acetate;

Reference yield:

: 52130-34-4
5-(3,4-dichlorophenyl)furfural

: 1297536-61-8
N-2-(2-(5-(3,4-dichlorophenyl)furan-2-yl)ethyl)-N-5-(2-hydroxyethyl)-pyrazine-2,5-dicarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: propylamine; acetic acid / methanol / 0 - 20 °C

2: hydrogenchloride; hydrogen / palladium 10% on activated carbon / ethyl acetate; methanol / 4 h / 20 °C / 2280.15 Torr

3: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane

4: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane

With hydrogenchloride; propylamine; hydrogen; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In methanol; dichloromethane; ethyl acetate;