N-(2-amino-2-oxoethyl)-3-(1-methylethyl)-1-[2-[3-(trifluoromethyl)benzyl]-1-benzothiophen-7-yl]-1H-pyrazole-4-carboxamide

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Chemical Name:N-(2-amino-2-oxoethyl)-3-(1-methylethyl)-1-[2-[3-(trifluoromethyl)benzyl]-1-benzothiophen-7-yl]-1H-pyrazole-4-carboxamide
CAS No.:1313197-03-3
Molecular Formula:C₂₅H₂₃F₃N₄O₂S
Molecular Weight:500.544
Hs Code.:

Synonyms:N-(2-amino-2-oxoethyl)-3-(1-methylethyl)-1-[2-[3-(trifluoromethyl)benzyl]-1-benzothiophen-7-yl]-1H-pyrazole-4-carboxamide

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Chemical Property of N-(2-amino-2-oxoethyl)-3-(1-methylethyl)-1-[2-[3-(trifluoromethyl)benzyl]-1-benzothiophen-7-yl]-1H-pyrazole-4-carboxamide

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Technology Process of N-(2-amino-2-oxoethyl)-3-(1-methylethyl)-1-[2-[3-(trifluoromethyl)benzyl]-1-benzothiophen-7-yl]-1H-pyrazole-4-carboxamide

There total 4 articles about N-(2-amino-2-oxoethyl)-3-(1-methylethyl)-1-[2-[3-(trifluoromethyl)benzyl]-1-benzothiophen-7-yl]-1H-pyrazole-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 11.0%

: 1313196-15-4
3-(1-methylethyl)-1-[2-[3-(trifluoromethyl)benzyl]-1-benzothiophen-7-yl]-1H-pyrazole-4-carboxylic acid

: 1668-10-6
glycinamide hydrochloride

: 1313197-03-3
N-(2-amino-2-oxoethyl)-3-(1-methylethyl)-1-[2-[3-(trifluoromethyl)benzyl]-1-benzothiophen-7-yl]-1H-pyrazole-4-carboxamide

Guidance literature:: 3-(1-methylethyl)-1-[2-[3-(trifluoromethyl)benzyl]-1-benzothiophen-7-yl]-1H-pyrazole-4-carboxylic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 10 - 35 ℃; for 0.0833333h;

glycinamide hydrochloride; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;

Reference yield:

: 342026-17-9
ethyl 3-isopropyl-1H-pyrazole-4-carboxylate

: 1313197-03-3
N-(2-amino-2-oxoethyl)-3-(1-methylethyl)-1-[2-[3-(trifluoromethyl)benzyl]-1-benzothiophen-7-yl]-1H-pyrazole-4-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / copper(II) acetate monohydrate / 55 °C

2: sodium hydroxide; water / ethanol; tetrahydrofuran / 3 h / 85 °C

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.08 h / 10 - 35 °C

With pyridine; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; copper(II) acetate monohydrate; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;

Reference yield:

: 1207970-76-0
4,4,5,5-tetramethyl-2-(2-(3-(trifluoromethyl)benzyl)-1-benzothiophen-7-yl)-1,3,2-dioxaborolane

: 1313197-03-3
N-(2-amino-2-oxoethyl)-3-(1-methylethyl)-1-[2-[3-(trifluoromethyl)benzyl]-1-benzothiophen-7-yl]-1H-pyrazole-4-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / copper(II) acetate monohydrate / 55 °C

2: sodium hydroxide; water / ethanol; tetrahydrofuran / 3 h / 85 °C

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.08 h / 10 - 35 °C

With pyridine; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; copper(II) acetate monohydrate; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;