N-CYCLOPROPYL L-VALINAMIDE

Base Information

• Chemical Name: N-CYCLOPROPYL L-VALINAMIDE
• CAS No.: 214139-86-3
• Molecular Formula: C₈H₁₆N₂O
• Molecular Weight: 156.228
• Mol file: 214139-86-3.mol

Synonyms:C₈H₁₆N₂O

Chemical Property of N-CYCLOPROPYL L-VALINAMIDE

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

N-CyclopropylL-Valinamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-CYCLOPROPYL L-VALINAMIDE

There total 2 articles about N-CYCLOPROPYL L-VALINAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C13H24N2O3 (1350980-67-4) → C8H16N2O (214139-86-3)

Guidance literature:

With trifluoroacetic acid; In dichloromethane;

DOI:10.1016/j.bmcl.2011.10.024

Reference yield:

t-Boc-L-valine (13734-41-3) → C8H16N2O (214139-86-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

2: trifluoroacetic acid / dichloromethane

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane;

DOI:10.1016/j.bmcl.2011.10.024

Reference yield:

4'-demethyl-4-deoxypodophyllotoxin 4'-(p-nitrophenyl) carbonate (1308813-97-9) + C8H16N2O (214139-86-3) → cyclopropyl N-(1-oxyl-4'-demethyl-4-deoxypodophyllic)-L-valine amide (1350980-63-0)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 20 ℃; for 0.166667h; Inert atmosphere;

DOI:10.1016/j.bmcl.2011.10.024

upstream raw materials:

C₁₃H₂₄N₂O₃

t-Boc-L-valine

Downstream raw materials:

cyclopropyl N-(1-oxyl-4'-demethyl-4-deoxypodophyllic)-L-valine amide

Refernces