(2E)-3-{2-[(4-bromobenzoyl)amino]-3-fluorophenyl}-2-propenoic acid methyl ester

Base Information

Chemical Name:(2E)-3-{2-[(4-bromobenzoyl)amino]-3-fluorophenyl}-2-propenoic acid methyl ester
CAS No.:690664-27-8
Molecular Formula:C₁₇H₁₃BrFNO₃
Molecular Weight:378.198
Hs Code.:

Synonyms:(2E)-3-{2-[(4-bromobenzoyl)amino]-3-fluorophenyl}-2-propenoic acid methyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2E)-3-{2-[(4-bromobenzoyl)amino]-3-fluorophenyl}-2-propenoic acid methyl ester

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Technology Process of (2E)-3-{2-[(4-bromobenzoyl)amino]-3-fluorophenyl}-2-propenoic acid methyl ester

There total 1 articles about (2E)-3-{2-[(4-bromobenzoyl)amino]-3-fluorophenyl}-2-propenoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 690664-20-1
methyl (2E)-3-(2-amino-3-fluorophenyl)acrylate

: 586-75-4
4-chlorobenzoyl chloride

: 690664-27-8
(2E)-3-{2-[(4-bromobenzoyl)amino]-3-fluorophenyl}-2-propenoic acid methyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 16h;

Reference yield: 55.0%

: 690664-27-8
(2E)-3-{2-[(4-bromobenzoyl)amino]-3-fluorophenyl}-2-propenoic acid methyl ester

: 98-16-8
3-trifluoromethylaniline

: 690664-30-3
{2-(4-bromophenyl)-8-fluoro-3-[3-(trifluoromethyl)phenyl]-3,4-dihydro-quinazolin-4-yl}-acetic acid methyl ester

Guidance literature:: With trichlorophosphate; In toluene; at 20 - 125 ℃; for 24 - 72h;

Reference yield: 23.0%

: 690664-27-8
(2E)-3-{2-[(4-bromobenzoyl)amino]-3-fluorophenyl}-2-propenoic acid methyl ester

: 349-65-5
2-Methoxy-5-trifluoromethyl-aniline

: {2-(4-bromo-phenyl)-8-fluoro-3-[2-methoxy-5-trifluoromethyl-phenyl]-3,4-dihydro-quinazolin-4-yl}-acetic acid methyl ester

Guidance literature:: (2E)-3-{2-[(4-bromobenzoyl)amino]-3-fluorophenyl}-2-propenoic acid methyl ester; With trichlorophosphate; In toluene; Heating / reflux;

2-Methoxy-5-trifluoromethyl-aniline; In toluene; Heating / reflux;