1-{4-[1-(pyridin-2-ylmethyl)-1H-1,2,3-triazol-4-yl]phenyl}-3-[4-(trifluoromethyl)phenyl]urea

Base Information

• Chemical Name: 1-{4-[1-(pyridin-2-ylmethyl)-1H-1,2,3-triazol-4-yl]phenyl}-3-[4-(trifluoromethyl)phenyl]urea
• CAS No.: 1351961-95-9
• Molecular Formula: C₂₂H₁₇F₃N₆O
• Molecular Weight: 438.412
• Mol file: 1351961-95-9.mol

Synonyms:1-{4-[1-(pyridin-2-ylmethyl)-1H-1,2,3-triazol-4-yl]phenyl}-3-[4-(trifluoromethyl)phenyl]urea

Chemical Property of 1-{4-[1-(pyridin-2-ylmethyl)-1H-1,2,3-triazol-4-yl]phenyl}-3-[4-(trifluoromethyl)phenyl]urea

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-{4-[1-(pyridin-2-ylmethyl)-1H-1,2,3-triazol-4-yl]phenyl}-3-[4-(trifluoromethyl)phenyl]urea

There total 1 articles about 1-{4-[1-(pyridin-2-ylmethyl)-1H-1,2,3-triazol-4-yl]phenyl}-3-[4-(trifluoromethyl)phenyl]urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2-azidomethylpyridine (609770-35-6) + 1-(4-ethynylphenyl)-3-(4-(trifluoromethyl)phenyl)urea (1200680-21-2) → 1-{4-[1-(pyridin-2-ylmethyl)-1H-1,2,3-triazol-4-yl]phenyl}-3-[4-(trifluoromethyl)phenyl]urea (1351961-95-9)

Guidance literature:

With copper(II) acetate monohydrate; In methanol; water; tert-butyl alcohol; at 25 ℃; for 18h; Inert atmosphere;

DOI:10.1039/c1ob06193c

Reference yield:

1-{4-[1-(pyridin-2-ylmethyl)-1H-1,2,3-triazol-4-yl]phenyl}-3-[4-(trifluoromethyl)phenyl]urea (1351961-95-9) → C16H36N(1+)*C23H20F3N6O(1+)*F(1-)*F6P(1-)

Guidance literature:

Multi-step reaction with 3 steps

1: chloroform; acetonitrile / 24 h / 50 °C / Inert atmosphere

2: ammonium hexafluorophosphate / water; acetonitrile / Inert atmosphere

3: acetonitrile / 25 °C / Inert atmosphere

With ammonium hexafluorophosphate; In chloroform; water; acetonitrile;

DOI:10.1039/c1ob06193c

Reference yield:

1-{4-[1-(pyridin-2-ylmethyl)-1H-1,2,3-triazol-4-yl]phenyl}-3-[4-(trifluoromethyl)phenyl]urea (1351961-95-9) → C16H36N(1+)*C23H20F3N6O(1+)*Cl(1-)*F6P(1-)

Guidance literature:

Multi-step reaction with 3 steps

1: chloroform; acetonitrile / 24 h / 50 °C / Inert atmosphere

2: ammonium hexafluorophosphate / water; acetonitrile / Inert atmosphere

3: acetonitrile / 25 °C / Inert atmosphere

With ammonium hexafluorophosphate; In chloroform; water; acetonitrile;

DOI:10.1039/c1ob06193c

upstream raw materials:

2-azidomethylpyridine

1-(4-ethynylphenyl)-3-(4-(trifluoromethyl)phenyl)urea

Downstream raw materials:

C₂H₃O₂^(1-)*C₁₆H₃₆N⁽¹⁺⁾*C₂₂H₁₇F₃N₆O