methyl 2-chloro-6-cyano-6-(3-cyclopentyloxy-4-methoxyphenyl)-1-oxospiro[2.5]octane-2-carboxylate

Base Information

• Chemical Name: methyl 2-chloro-6-cyano-6-(3-cyclopentyloxy-4-methoxyphenyl)-1-oxospiro[2.5]octane-2-carboxylate
• CAS No.: 326008-99-5
• Molecular Formula: C₂₂H₂₆ClNO₅
• Molecular Weight: 419.905
• Mol file: 326008-99-5.mol

Synonyms:methyl 2-chloro-6-cyano-6-(3-cyclopentyloxy-4-methoxyphenyl)-1-oxospiro[2.5]octane-2-carboxylate

Chemical Property of methyl 2-chloro-6-cyano-6-(3-cyclopentyloxy-4-methoxyphenyl)-1-oxospiro[2.5]octane-2-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2-chloro-6-cyano-6-(3-cyclopentyloxy-4-methoxyphenyl)-1-oxospiro[2.5]octane-2-carboxylate

There total 1 articles about methyl 2-chloro-6-cyano-6-(3-cyclopentyloxy-4-methoxyphenyl)-1-oxospiro[2.5]octane-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

dichloroacetic acid methyl ester (116-54-1) + 4-cyano-4-[3-(cyclopentyloxy)-4-methoxyphenyl]cyclohexan-1-one (152630-47-2) → methyl 2-chloro-6-cyano-6-(3-cyclopentyloxy-4-methoxyphenyl)-1-oxospiro[2.5]octane-2-carboxylate (326008-99-5)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; at 0 - 5 ℃; for 0.5h;

DOI:10.1021/op025584z

Reference yield: 85.0%

methyl 2-chloro-6-cyano-6-(3-cyclopentyloxy-4-methoxyphenyl)-1-oxospiro[2.5]octane-2-carboxylate (326008-99-5) → 2-chloro-6-cyano-6-(3-cyclopentyloxy-4-methoxyphenyl)-1-oxospiro[2.5]octane-2-carboxylic acid

Guidance literature:

With sodium methylate; In methanol; water; for 0.25h;

DOI:10.1021/op025584z

Reference yield:

methyl 2-chloro-6-cyano-6-(3-cyclopentyloxy-4-methoxyphenyl)-1-oxospiro[2.5]octane-2-carboxylate (326008-99-5) → cilomilast (153259-65-5,164414-71-5)

Guidance literature:

methyl 2-chloro-6-cyano-6-(3-cyclopentyloxy-4-methoxyphenyl)-1-oxospiro[2.5]octane-2-carboxylate; With sodium methylate; In methanol; water; for 0.25h;

With hydrogenchloride; In tert-butyl methyl ether; water;

With potassium tert-butylate; sodium chloride; more than 3 stages;

upstream raw materials:

dichloroacetic acid methyl ester

4-cyano-4-[3-(cyclopentyloxy)-4-methoxyphenyl]cyclohexan-1-one

Downstream raw materials:

cilomilast

cilomilast