1-(4-cyanobenzyl)-4-oxo-5-(3-(trifluoromethyl)phenyl)-1,4-dihydropyridine-3-carboxylic acid 4-methanesulfonylbenzylamide

Base Information

Chemical Name:1-(4-cyanobenzyl)-4-oxo-5-(3-(trifluoromethyl)phenyl)-1,4-dihydropyridine-3-carboxylic acid 4-methanesulfonylbenzylamide
CAS No.:1571134-67-2
Molecular Formula:C₂₉H₂₂F₃N₃O₄S
Molecular Weight:565.573
Hs Code.:

Synonyms:1-(4-cyanobenzyl)-4-oxo-5-(3-(trifluoromethyl)phenyl)-1,4-dihydropyridine-3-carboxylic acid 4-methanesulfonylbenzylamide

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Chemical Property of 1-(4-cyanobenzyl)-4-oxo-5-(3-(trifluoromethyl)phenyl)-1,4-dihydropyridine-3-carboxylic acid 4-methanesulfonylbenzylamide

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Technology Process of 1-(4-cyanobenzyl)-4-oxo-5-(3-(trifluoromethyl)phenyl)-1,4-dihydropyridine-3-carboxylic acid 4-methanesulfonylbenzylamide

There total 5 articles about 1-(4-cyanobenzyl)-4-oxo-5-(3-(trifluoromethyl)phenyl)-1,4-dihydropyridine-3-carboxylic acid 4-methanesulfonylbenzylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: 1571135-37-9
1-(4-cyanobenzyl)-4-oxo-5-(3-(trifluoromethyl)phenyl)-1,4-dihydropyridine-3-carboxylic acid

: 98593-51-2
4-(methylsulfonyl)benzylamine hydrochloride

: 1571134-67-2
1-(4-cyanobenzyl)-4-oxo-5-(3-(trifluoromethyl)phenyl)-1,4-dihydropyridine-3-carboxylic acid 4-methanesulfonylbenzylamide

Guidance literature:: 1-(4-cyanobenzyl)-4-oxo-5-(3-(trifluoromethyl)phenyl)-1,4-dihydropyridine-3-carboxylic acid; With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.25h;

4-(methylsulfonyl)benzylamine hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 18h;

Reference yield:

: 17201-43-3
4-cyanobenzyl bromide

: 1571134-67-2
1-(4-cyanobenzyl)-4-oxo-5-(3-(trifluoromethyl)phenyl)-1,4-dihydropyridine-3-carboxylic acid 4-methanesulfonylbenzylamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h

1.2: 2 h / 20 °C

2.1: acetic acid; bromine / 192 h / 20 °C

3.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate / 1,4-dioxane / 24 h / 60 °C

4.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 0.25 h / 20 °C

4.2: 18 h / 20 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; O-(benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate; bromine; sodium hydride; caesium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; N,N-dimethyl-formamide; mineral oil; 3.1: |Suzuki Coupling;

Reference yield:

: 1571135-38-0
1-(4-cyanobenzyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid

: 1571134-67-2
1-(4-cyanobenzyl)-4-oxo-5-(3-(trifluoromethyl)phenyl)-1,4-dihydropyridine-3-carboxylic acid 4-methanesulfonylbenzylamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic acid; bromine / 192 h / 20 °C

2.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate / 1,4-dioxane / 24 h / 60 °C

3.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 0.25 h / 20 °C

3.2: 18 h / 20 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; O-(benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate; bromine; caesium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; N,N-dimethyl-formamide; 2.1: |Suzuki Coupling;