4-(4-acetyl phenyl amino)-6-methoxy-2-phenylquinoline

Base Information

• Chemical Name: 4-(4-acetyl phenyl amino)-6-methoxy-2-phenylquinoline
• CAS No.: 867017-08-1
• Molecular Formula: C₂₄H₂₀N₂O₂
• Molecular Weight: 368.435
• Mol file: 867017-08-1.mol

Synonyms:4-(4-acetyl phenyl amino)-6-methoxy-2-phenylquinoline

Chemical Property of 4-(4-acetyl phenyl amino)-6-methoxy-2-phenylquinoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(4-acetyl phenyl amino)-6-methoxy-2-phenylquinoline

There total 6 articles about 4-(4-acetyl phenyl amino)-6-methoxy-2-phenylquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

4-chloro-6-methoxy-2-phenylquinoline (50593-72-1) + p-aminobenzophenone (99-92-3) → 4-(4-acetyl phenyl amino)-6-methoxy-2-phenylquinoline (867017-08-1)

Guidance literature:

With pyridine; In 2-ethoxy-ethanol; Heating;

DOI:10.1016/j.ejmech.2005.03.008

Reference yield:

2-[(4-methoxy-phenylamino)-phenyl-methylene]-malonic acid diethyl ester (828264-17-1) → 4-(4-acetyl phenyl amino)-6-methoxy-2-phenylquinoline (867017-08-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 82 percent / diphenyl ether / 1 h / 230 - 250 °C

2: 85 percent / NaOH / ethanol / 6 h / Heating

3: 92 percent / POCl₃ / Heating

4: 62 percent / pyridine / 2-ethoxy-ethanol / Heating

With pyridine; sodium hydroxide; trichlorophosphate; In 2-ethoxy-ethanol; diphenylether; ethanol;

DOI:10.1016/j.ejmech.2005.03.008

Reference yield:

ethyl 6-methoxy-4-oxo-2-phenyl-1,4-dihydroquinoline-3-carboxylate (93663-71-9,828264-32-0) → 4-(4-acetyl phenyl amino)-6-methoxy-2-phenylquinoline (867017-08-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 85 percent / NaOH / ethanol / 6 h / Heating

2: 92 percent / POCl₃ / Heating

3: 62 percent / pyridine / 2-ethoxy-ethanol / Heating

With pyridine; sodium hydroxide; trichlorophosphate; In 2-ethoxy-ethanol; ethanol;

DOI:10.1016/j.ejmech.2005.03.008

upstream raw materials:

4-chloro-6-methoxy-2-phenylquinoline

p-aminobenzophenone

ethyl 6-methoxy-4-oxo-2-phenyl-1,4-dihydroquinoline-3-carboxylate

2-[(4-methoxy-phenylamino)-phenyl-methylene]-malonic acid diethyl ester

Refernces