N-[(2-{2-[(Z)-Hydroxyimino]-propionylamino}-ethylcarbamoyl)-methyl]-2-nitro-benzamide

Base Information

• Chemical Name: N-[(2-{2-[(Z)-Hydroxyimino]-propionylamino}-ethylcarbamoyl)-methyl]-2-nitro-benzamide
• CAS No.: 66472-65-9
• Molecular Formula: C₁₄H₁₇N₅O₆
• Molecular Weight: 351.319

Synonyms:N-[(2-{2-[(Z)-Hydroxyimino]-propionylamino}-ethylcarbamoyl)-methyl]-2-nitro-benzamide

Chemical Property of N-[(2-{2-[(Z)-Hydroxyimino]-propionylamino}-ethylcarbamoyl)-methyl]-2-nitro-benzamide

Chemical Property:

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Technology Process of N-[(2-{2-[(Z)-Hydroxyimino]-propionylamino}-ethylcarbamoyl)-methyl]-2-nitro-benzamide

There total 3 articles about N-[(2-{2-[(Z)-Hydroxyimino]-propionylamino}-ethylcarbamoyl)-methyl]-2-nitro-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-{2-[2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-acetylamino]-ethyl}-2-[(E)-hydroxyimino]-propionamide (66472-67-1) → N-[(2-{2-[(Z)-Hydroxyimino]-propionylamino}-ethylcarbamoyl)-methyl]-2-nitro-benzamide (66472-65-9)

Guidance literature:

Multi-step reaction with 2 steps

1: N₂H₄*H₂O / ethanol

2: aq. NaHCO₃ / acetonitrile

With sodium hydrogencarbonate; hydrazine hydrate; In ethanol; acetonitrile;

DOI:10.1021/ja00474a033

Reference yield:

N-Aminoacetyl-N'-(2-hydroxyiminopropionyl)ethylendiamin (66472-66-0) + 2-nitrobenzyl chloride (610-14-0) → N-[(2-{2-[(Z)-Hydroxyimino]-propionylamino}-ethylcarbamoyl)-methyl]-2-nitro-benzamide (66472-65-9)

Guidance literature:

With sodium hydrogencarbonate; In acetonitrile;

DOI:10.1021/ja00474a033

Reference yield:

N-(2-nitrobenzoyl)glycine (10167-23-4) + N-2-aminoethyl-2-hydroxyiminopropanamide (66472-57-9) → N-[(2-{2-[(Z)-Hydroxyimino]-propionylamino}-ethylcarbamoyl)-methyl]-2-nitro-benzamide (66472-65-9)

Guidance literature:

Multistep reaction; (i) ClCO₂Et, Et₃N, THF, (ii) /BRN= 2077346/;

DOI:10.1021/ja00474a033

upstream raw materials:

N-(2-nitrobenzoyl)glycine

N-2-aminoethyl-2-hydroxyiminopropanamide

N-Aminoacetyl-N'-(2-hydroxyiminopropionyl)ethylendiamin

2-nitrobenzyl chloride

Downstream raw materials:

2-Amino-N-[(2-{2-[(E)-hydroxyimino]-propionylamino}-ethylcarbamoyl)-methyl]-benzamide

1-o-Aminophenyl-10-methyl-2,5,8,11-tetraazaundecan

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