10167-23-4

Usage

Uses

Used in Organic Synthesis:
o-Nitrobenzoylglycine is used as a key intermediate for the synthesis of various organic compounds and pharmaceuticals. Its unique structure and functional groups make it a valuable building block in the development of new chemical entities.
Used in Pharmaceutical Industry:
o-Nitrobenzoylglycine is used as a precursor in the production of pharmaceuticals. Its potential biological activities, such as anti-inflammatory and antifungal properties, contribute to the development of new drugs for treating various diseases and conditions.
Used in Research Laboratories:
o-Nitrobenzoylglycine is used as a research chemical in laboratories to study its properties and explore its potential applications in synthetic chemistry and pharmacology. Its presence in research settings facilitates the discovery of new reactions and the development of innovative synthetic routes.
Used in Chemical Industries:
o-Nitrobenzoylglycine is utilized in the chemical industry for the large-scale production of organic compounds and pharmaceuticals. Its versatility and reactivity make it an essential component in the manufacturing processes of various chemical products.

Upstream product

• 5177-49-1 ethyl 2-(2-nitrobenzamido)acetate 
• 56-40-6 glycine 
• 610-14-0 2-nitrobenzyl chloride 
• 552-16-9 ortho-nitrobenzoic acid 
• 623-33-6 glycine ethyl ester hydrochloride 

Downstream Products

• 526-21-6 N-(2-aminobenzoyl)-glycine 
• 25673-44-3 4-(Z)-benzylidene-2-(2-nitro-phenyl)-4H-oxazol-5-one 
• 4211-97-6 2-(2-nitro-phenyl)-4-thiophen-2-ylmethylene-4H-oxazol-5-one 
• 41089-53-6 N(o-Nitrobenzoyl)glycylalanin 
• 66472-65-9 N-[(2-{2-[(Z)-Hydroxyimino]-propionylamino}-ethylcarbamoyl)-methyl]-2-nitro-benzamide 
• 19500-42-6 3,3'-{4-[2-(2-nitro-phenyl)-5-oxo-oxazol-4-ylidenemethyl]-phenylazanediyl}-bis-propionitrile 
• 20063-40-5 3,3'-{3-methyl-4-[2-(2-nitro-phenyl)-5-oxo-oxazol-4-ylidenemethyl]-phenylazanediyl}-bis-propionitrile 
• 39052-67-0 4-[4-(benzyl-methyl-amino)-benzylidene]-2-(2-nitro-phenyl)-4H-oxazol-5-one 
• 58352-46-8 N-(N-acetyl-anthraniloyl)-glycine 
• 1224962-90-6 C₁₁H₁₀N₂O₆ 
• 313970-63-7 4-(4-nitrobenzylidene)-2-(2-nitrophenyl)-5(4H)-oxazolone 

Relevant academic research and scientific papers

Synthesis and Quantitative Structure-activity Relationships Study for Arylpropenamide Derivatives as Inhibitors of Hepatitis B Virus Replication

A series of new arylpropenamide derivatives containing different aryl groups were synthesized, characterized, and evaluated for their anti-hepatitis B virus (HBV) activities. A new high accuracy QSAR model of arylpropenamide was constructed based on a more completely activities data and calculation parameter. The 2D-QSAR equations, by using DFT and multiple linear regression analysis methods, revealed that higher value of thermal energy (TE) and lower entropy (S?) increase the anti-HBV activities of the arylpropenamide molecules. Predictive 3D-QSAR models were established by SYBYL multifit molecular alignment rule. The optimum models were all statistically significant with cross-validated and conventional coefficients, indicating that they were reliable enough for activity prediction.

Substituents effect on the erlenmeyer-ploechl reaction: Understanding an observed process reaction time

A systematic study on hippuric acid substituents was performed in order to better understand the influence of stereoelectronic factors on the Erlenmeyer reaction rate. In addition, two reaction systems were evaluated: Huenig's base solvent free conditions and catalytic sodium acetate in 2-methyl-THF. The effect on reaction rate of electron withdrawing and electron donating groups are reported. Specifically, the study led to the conclusion that stereoelectronic factors have significant influence in one of our key Erlenmeyer reaction by affecting its reaction rate.

Synthesis and in Vitro Aldolase Reductase Inhibitory Activity of Compounds Containing an N-Acylglycine Moiety

A number of N-benzoylglycines (6), N-acetyl-N-phenylglycines (7), N-benzoyl-N-phenylglycines (8), and tricyclic N-acetic acids (9-12) were synthesized as analogues of the N-acylglycine-containing aldolase reductase inhibitors alrestatin and 2-oxoquinoline-1-acetic acid.Derivatives of 6, which represent ring-simplified analogues of alrestatin, are very weak inhibitors of aldolase reductase obtained from rat lens, producing 50percent inhibition only at concentrations exceeding 100 μM.Compounds of series 7 were designed as ring-opened analogues of the 2-oxoquinolines.While this derivatives are more potent than compounds of series 6 (IC 50s of 6-80 μM), they are less active than the corresponding 2-oxoquinolines.Analogues of series 8 were designed as hybrid structures of both alrestatin and the 2-oxoquinoline-1-acetic acids.These compounds are substantially more potent than compounds of series 6 and 7 and display inhibitory activities comparable to or greater than alrestatin or the 2-oxoquinolines (IC 50s of 0.1-10 μM).Of the rigid analogues of 8, the most potent derivative is benzoxindol (12) with an IC 50 of 0.67 μM, suggesting that fusion of the two aromatic rings of 8 in a coplanar conformation may optimize affinity for aldose reductase in this series.