tert-butyl (R)-3-<(S)-carboxy-3-phenylpropyl>amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepine-5-acetate

Base Information

Chemical Name:tert-butyl (R)-3-<(S)-carboxy-3-phenylpropyl>amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepine-5-acetate
CAS No.:98413-69-5
Molecular Formula:C₂₅H₃₀N₂O₅S
Molecular Weight:470.59
Hs Code.:

Synonyms:tert-butyl (R)-3-<(S)-carboxy-3-phenylpropyl>amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepine-5-acetate

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Chemical Property of tert-butyl (R)-3-<(S)-carboxy-3-phenylpropyl>amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepine-5-acetate

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Technology Process of tert-butyl (R)-3-<(S)-carboxy-3-phenylpropyl>amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepine-5-acetate

There total 13 articles about tert-butyl (R)-3-<(S)-carboxy-3-phenylpropyl>amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepine-5-acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 95779-48-9
tert-butyl 3(R)-[1(S)-ethoxycarbonyl-3-phenylpropyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepine-5-acetate

: 98413-69-5
tert-butyl (R)-3-<(S)-carboxy-3-phenylpropyl>amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepine-5-acetate

Guidance literature:: With sodium hydroxide; In water; for 2h; Ambient temperature;
DOI:10.1248/cpb.34.1128

Reference yield:

: 95779-47-8
tert-butyl 3(R)-[1(R)-ethoxycarbonyl-3-phenylpropyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepine-5-acetate

: 95779-48-9
tert-butyl 3(R)-[1(S)-ethoxycarbonyl-3-phenylpropyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepine-5-acetate

: 98413-69-5
tert-butyl (R)-3-<(S)-carboxy-3-phenylpropyl>amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepine-5-acetate

Guidance literature:: With hydrogenchloride; sodium hydroxide; In ethanol; water;

Reference yield:

: 60115-45-9
S-(o-nitrophenyl)-L-cysteine

: 98413-69-5
tert-butyl (R)-3-<(S)-carboxy-3-phenylpropyl>amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepine-5-acetate

Guidance literature:: Multi-step reaction with 7 steps

1: 81 percent / Na₂CO₃ / H₂O / 5 h / Ambient temperature

2: 91 percent / H₂ / 5percent Pd-C / methanol / Ambient temperature

3: 68 percent / DEPC, Et₃N / dimethylformamide / 1) 35 min 0 deg C 2) 1 h r.t.

4: 74 percent / NaH / dimethylformamide / 0.33 h

5: 71 percent / N₂H₄*H₂O / ethanol / 1 h / Heating

6: 31 percent / NaBH₃CN, molecular sieves 4 Angstroem / acetic acid; ethanol / Ambient temperature

7: 66 percent / 1 N NaOH / H₂O / 2 h / Ambient temperature

With sodium hydroxide; 4 A molecular sieve; hydrogen; sodium hydride; sodium cyanoborohydride; sodium carbonate; hydrazine hydrate; triethylamine; diethyl dicarbonate; palladium on activated charcoal; In methanol; ethanol; water; acetic acid; N,N-dimethyl-formamide;
DOI:10.1248/cpb.34.1128