dimethyl N-<4-<3-(2-pivaloylamino-4(3H)-oxo-5,6,7,8-tetrahydropyrido<2,3-d>pyrimidin-6-yl)-1,1-dimethyl-1-silapropyl>benzoyl>-L-glutamate

Base Information

Chemical Name:dimethyl N-<4-<3-(2-pivaloylamino-4(3H)-oxo-5,6,7,8-tetrahydropyrido<2,3-d>pyrimidin-6-yl)-1,1-dimethyl-1-silapropyl>benzoyl>-L-glutamate
CAS No.:221238-95-5
Molecular Formula:C₃₀H₄₃N₅O₇Si
Molecular Weight:613.786
Hs Code.:

Synonyms:dimethyl N-<4-<3-(2-pivaloylamino-4(3H)-oxo-5,6,7,8-tetrahydropyrido<2,3-d>pyrimidin-6-yl)-1,1-dimethyl-1-silapropyl>benzoyl>-L-glutamate

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Chemical Property of dimethyl N-<4-<3-(2-pivaloylamino-4(3H)-oxo-5,6,7,8-tetrahydropyrido<2,3-d>pyrimidin-6-yl)-1,1-dimethyl-1-silapropyl>benzoyl>-L-glutamate

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Technology Process of dimethyl N-<4-<3-(2-pivaloylamino-4(3H)-oxo-5,6,7,8-tetrahydropyrido<2,3-d>pyrimidin-6-yl)-1,1-dimethyl-1-silapropyl>benzoyl>-L-glutamate

There total 6 articles about dimethyl N-<4-<3-(2-pivaloylamino-4(3H)-oxo-5,6,7,8-tetrahydropyrido<2,3-d>pyrimidin-6-yl)-1,1-dimethyl-1-silapropyl>benzoyl>-L-glutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: dimethyl N-<4-<3-(2-pivaloylamino-4(3H)-oxopyrido<2,3-d>pyrimidin-6-yl)-1,1-dimethyl-1-sila-2-propenyl>benzoyl>-L-glutamate

: 221238-95-5
dimethyl N-<4-<3-(2-pivaloylamino-4(3H)-oxo-5,6,7,8-tetrahydropyrido<2,3-d>pyrimidin-6-yl)-1,1-dimethyl-1-silapropyl>benzoyl>-L-glutamate

Guidance literature:: With hydrogen; platinum(IV) oxide; In methanol; for 12h; under 2585.74 Torr;
DOI:10.1016/S0040-4020(98)01207-1

Reference yield:

: 32664-14-5
2-(4-bromophenyl)-4,4-dimethyl-2-oxazoline

: 221238-95-5
dimethyl N-<4-<3-(2-pivaloylamino-4(3H)-oxo-5,6,7,8-tetrahydropyrido<2,3-d>pyrimidin-6-yl)-1,1-dimethyl-1-silapropyl>benzoyl>-L-glutamate

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) Mg, I₂ / 1.) THF, reflux, 5.5 h, 2.) THF, 4 deg C to room temperature, overnight; reflux, 1 h

2: acetonitrile / 48 h / 120 °C

3: aq. NaOH / 24 h / Ambient temperature

4: 1.) 2-chloro-4,6-dimethoxy-1,3,5-triazine, N-methylmorpholine, 2.) N-methylmorpholine / 1.) CH₂Cl₂, 4 deg C, 2 h, 2.) 4 deg C to room temperature, overnight

5: 85 percent / Et₃N, palladium acetate, CuI, tri-o-tolylphosphine / acetonitrile / 12 h / Heating

6: 95 percent / H₂ / PtO₂ / methanol / 12 h / 2585.74 Torr

With 4-methyl-morpholine; sodium hydroxide; copper(l) iodide; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; hydrogen; iodine; palladium diacetate; magnesium; triethylamine; tris-(o-tolyl)phosphine; platinum(IV) oxide; In methanol; acetonitrile;
DOI:10.1016/S0040-4020(98)01207-1

Reference yield:

: 66259-07-2
4-(vinyldimethylsilyl)benzoic acid

: 221238-95-5
dimethyl N-<4-<3-(2-pivaloylamino-4(3H)-oxo-5,6,7,8-tetrahydropyrido<2,3-d>pyrimidin-6-yl)-1,1-dimethyl-1-silapropyl>benzoyl>-L-glutamate

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) 2-chloro-4,6-dimethoxy-1,3,5-triazine, N-methylmorpholine, 2.) N-methylmorpholine / 1.) CH₂Cl₂, 4 deg C, 2 h, 2.) 4 deg C to room temperature, overnight

2: 85 percent / Et₃N, palladium acetate, CuI, tri-o-tolylphosphine / acetonitrile / 12 h / Heating

3: 95 percent / H₂ / PtO₂ / methanol / 12 h / 2585.74 Torr

With 4-methyl-morpholine; copper(l) iodide; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; hydrogen; palladium diacetate; triethylamine; tris-(o-tolyl)phosphine; platinum(IV) oxide; In methanol; acetonitrile;
DOI:10.1016/S0040-4020(98)01207-1