N₆-cyclohexyl-N₂-(2-methyl-4-morpholin-4-yl-phenyl)-9-(tetrahydropyran-2-yl)-9H-purine-2,6-diamine

Base Information

• Chemical Name: N₆-cyclohexyl-N₂-(2-methyl-4-morpholin-4-yl-phenyl)-9-(tetrahydropyran-2-yl)-9H-purine-2,6-diamine
• CAS No.: 1246532-46-6
• Molecular Formula: C₂₇H₃₇N₇O₂
• Molecular Weight: 491.636

Synonyms:N₆-cyclohexyl-N₂-(2-methyl-4-morpholin-4-yl-phenyl)-9-(tetrahydropyran-2-yl)-9H-purine-2,6-diamine

Chemical Property of N₆-cyclohexyl-N₂-(2-methyl-4-morpholin-4-yl-phenyl)-9-(tetrahydropyran-2-yl)-9H-purine-2,6-diamine

Chemical Property:

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Technology Process of N₆-cyclohexyl-N₂-(2-methyl-4-morpholin-4-yl-phenyl)-9-(tetrahydropyran-2-yl)-9H-purine-2,6-diamine

There total 4 articles about N₆-cyclohexyl-N₂-(2-methyl-4-morpholin-4-yl-phenyl)-9-(tetrahydropyran-2-yl)-9H-purine-2,6-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

2-Methyl-4-morpholin-4-ylphenylamine (581-00-0) + 2-chloro-N-cyclohexyl-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-amine (1246532-45-5) → N6-cyclohexyl-N2-(2-methyl-4-morpholin-4-yl-phenyl)-9-(tetrahydropyran-2-yl)-9H-purine-2,6-diamine (1246532-46-6)

Guidance literature:

With caesium carbonate; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In toluene; at 100 ℃; Inert atmosphere;

Reference yield:

4-(3-methyl-4-nitrophenyl)morpholine (220679-09-4) → N6-cyclohexyl-N2-(2-methyl-4-morpholin-4-yl-phenyl)-9-(tetrahydropyran-2-yl)-9H-purine-2,6-diamine (1246532-46-6)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / methanol

2: palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 80 - 100 °C

With palladium 10% on activated carbon; hydrogen; palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In methanol; toluene; 2: Buchwald coupling;

DOI:10.1016/j.bmcl.2012.04.131

Reference yield:

cyclohexylamine (108-91-8,157973-60-9) → N6-cyclohexyl-N2-(2-methyl-4-morpholin-4-yl-phenyl)-9-(tetrahydropyran-2-yl)-9H-purine-2,6-diamine (1246532-46-6)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / ethanol / 80 °C

2: toluene-4-sulfonic acid / tetrahydrofuran / Reflux

3: palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 80 - 100 °C

With palladium diacetate; caesium carbonate; toluene-4-sulfonic acid; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; triethylamine; In tetrahydrofuran; ethanol; toluene; 3: Buchwald coupling;

DOI:10.1016/j.bmcl.2012.04.131

upstream raw materials:

2-Methyl-4-morpholin-4-ylphenylamine

2-chloro-N-cyclohexyl-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-amine

4-(3-methyl-4-nitrophenyl)morpholine

cyclohexylamine

Downstream raw materials:

MPI-0479605

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