1,3-DIMETHOXY-5-(2-NITROPROP-1-ENYL)BENZENE

Base Information

• Chemical Name: 1,3-DIMETHOXY-5-(2-NITROPROP-1-ENYL)BENZENE
• CAS No.: 18917-76-5
• Molecular Formula: C11H13 N O4
• Molecular Weight: 223.229
• Hs Code.: 2909309090
• Mol file: 18917-76-5.mol

Synonyms:Benzene,1,3-dimethoxy-5-(2-nitro-1-propenyl)- (9CI); Benzene,1,3-dimethoxy-5-(2-nitropropenyl)- (7CI,8CI)

Chemical Property of 1,3-DIMETHOXY-5-(2-NITROPROP-1-ENYL)BENZENE

Chemical Property:

• Vapor Pressure: 5.4E-05mmHg at 25°C
• Melting Point: 87 °C
• Boiling Point: 358°Cat760mmHg
• Flash Point: 159.4°C
• PSA: 64.28000
• Density: 1.168g/cm³
• LogP: 2.86450

Purity/Quality:

98%min ^*data from raw suppliers

1,3-Dimethoxy-5-(2-nitroprop-1-en-1-yl)benzene 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R36/37/38:Irritating to eyes, respiratory system and skin.
• Hazard Codes: Xi:Irritant
• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,3-DIMETHOXY-5-(2-NITROPROP-1-ENYL)BENZENE

There total 1 articles about 1,3-DIMETHOXY-5-(2-NITROPROP-1-ENYL)BENZENE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

Nitroethane (79-24-3) + 3,5-dimethoxybenzaldehdye (7311-34-4) → 1,3-dimethoxy-5-(2-nitroprop-1-en-1-yl)benzene (18917-76-5)

Guidance literature:

With ammonium acetate; for 4h; Reflux;

DOI:10.1016/j.tet.2015.08.005

Reference yield: 90.0%

1,3-dimethoxy-5-(2-nitroprop-1-en-1-yl)benzene (18917-76-5) → (3,5-dimethoxyphenyl)acetone (18917-77-6)

Guidance literature:

With iron; acetic acid; for 3h; Heating;

DOI:10.1002/jhet.5570330460

Reference yield: 78.0%

1,3-dimethoxy-5-(2-nitroprop-1-en-1-yl)benzene (18917-76-5) + N-bromoacetamide (79-15-2) → 1-acetylamino-2-bromo-1-(3,5-dimethoxyphenyl)-2-nitropropane (1215288-80-4)

Guidance literature:

With potassium phosphate; In dichloromethane; at 20 ℃; for 24h; regiospecific reaction;

DOI:10.1021/jo9026879

upstream raw materials:

Nitroethane

3,5-dimethoxybenzaldehdye

Downstream raw materials:

1-(3,5-dimethoxyphenyl)propan-2-amine

3-(3,5-Dimethoxy-phenyl)-4-methyl-1H-pyrrole-2-carboxylic acid ethyl ester

(3,5-dimethoxyphenyl)acetone

(R,R)-N-<1-(3,5-dimethoxyphenyl)-2-propyl>-α-methylbenzenemethanamine

Refernces

• 1、 -. "Novel dihydroquinolizinones for the treatment and prophylaxis of hepatitis B virus infection". Paragraph 0706; 0707. . Retrieved 2015/08/04.
• 2、 Upender,Pollart,Liu,Hobbs,Olsen,Chao,Bowden,Crase,Thomas,Pandey,Lawson,Dawson. "The synthesis and biological activity of two analogs of the anti-HIV alkaloid michellamine B". . p. 1371 - 1385. Retrieved 2007/10/03.