6-<<2,2-bis(benzyloxymethyl)cyclopropyl>amino>-4-chloro-2,5-diformamidopyrimidine

Base Information

Chemical Name:6-<<2,2-bis(benzyloxymethyl)cyclopropyl>amino>-4-chloro-2,5-diformamidopyrimidine
CAS No.:145215-24-3
Molecular Formula:C₂₅H₂₆ClN₅O₄
Molecular Weight:495.966
Hs Code.:

Synonyms:6-<<2,2-bis(benzyloxymethyl)cyclopropyl>amino>-4-chloro-2,5-diformamidopyrimidine

Suppliers and Price of 6-<<2,2-bis(benzyloxymethyl)cyclopropyl>amino>-4-chloro-2,5-diformamidopyrimidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 6-<<2,2-bis(benzyloxymethyl)cyclopropyl>amino>-4-chloro-2,5-diformamidopyrimidine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 6-<<2,2-bis(benzyloxymethyl)cyclopropyl>amino>-4-chloro-2,5-diformamidopyrimidine

There total 8 articles about 6-<<2,2-bis(benzyloxymethyl)cyclopropyl>amino>-4-chloro-2,5-diformamidopyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.7%

: 116477-30-6
4,6-dichloro-2,5-diformamido-pyrimidine

: 135345-86-7
2,2-bis(benzyloxymethyl)cyclopropylamine

: 145215-24-3
6-<<2,2-bis(benzyloxymethyl)cyclopropyl>amino>-4-chloro-2,5-diformamidopyrimidine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; 1.) room temperature, 7 h, 2.) 70 deg C, 2 h;
DOI:10.1039/P19920002519

Reference yield:

: 27441-79-8
2-methylenepropane-1,3-bisbenzyl ether

: 145215-24-3
6-<<2,2-bis(benzyloxymethyl)cyclopropyl>amino>-4-chloro-2,5-diformamidopyrimidine

Guidance literature:: Multi-step reaction with 7 steps

1: 56.2 percent / cupric sulfate / 0.5 h / 90 °C

2: 84.7 percent / KOH / methanol / Ambient temperature

3: 1.) ClCO₂Et, Et₃N, 2.) NaN₃ / 1.) acetone, 0 deg C, 1 h, 2.) H₂O, room temperature, 1 h

4: 12.8 g / toluene / 1 h / 90 - 100 °C

5: 84.8 percent / 48 h / 90 - 100 °C

6: 100 percent / CF₃CO₂H / 0.33 h / Ambient temperature

7: 90.7 percent / diisopropylethylamine / dioxane / 1.) room temperature, 7 h, 2.) 70 deg C, 2 h

With potassium hydroxide; sodium azide; chloroformic acid ethyl ester; copper(II) sulfate; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In 1,4-dioxane; methanol; toluene;
DOI:10.1039/P19920002519

Reference yield:

: 135345-84-5
1,1-bis(benzyloxymethyl)cyclopropane-2-carboxylic acid

: 145215-24-3
6-<<2,2-bis(benzyloxymethyl)cyclopropyl>amino>-4-chloro-2,5-diformamidopyrimidine

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) ClCO₂Et, Et₃N, 2.) NaN₃ / 1.) acetone, 0 deg C, 1 h, 2.) H₂O, room temperature, 1 h

2: 12.8 g / toluene / 1 h / 90 - 100 °C

3: 84.8 percent / 48 h / 90 - 100 °C

4: 100 percent / CF₃CO₂H / 0.33 h / Ambient temperature

5: 90.7 percent / diisopropylethylamine / dioxane / 1.) room temperature, 7 h, 2.) 70 deg C, 2 h

With sodium azide; chloroformic acid ethyl ester; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In 1,4-dioxane; toluene;
DOI:10.1039/P19920002519