(+/-)-2-phenyl-5-<(dimethylamino)methyl>isoxazolidin-3-one

Base Information

Chemical Name:(+/-)-2-phenyl-5-<(dimethylamino)methyl>isoxazolidin-3-one
CAS No.:140176-85-8
Molecular Formula:C₁₂H₁₆N₂O₂
Molecular Weight:220.271
Hs Code.:

Synonyms:(+/-)-2-phenyl-5-<(dimethylamino)methyl>isoxazolidin-3-one

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Chemical Property of (+/-)-2-phenyl-5-<(dimethylamino)methyl>isoxazolidin-3-one

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Technology Process of (+/-)-2-phenyl-5-<(dimethylamino)methyl>isoxazolidin-3-one

There total 12 articles about (+/-)-2-phenyl-5-<(dimethylamino)methyl>isoxazolidin-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 2-Phenyl-5-trifluoromethoxymethyl-isoxazolidin-3-one

: 124-40-3
dimethyl amine

: 140176-85-8
(+/-)-2-phenyl-5-<(dimethylamino)methyl>isoxazolidin-3-one

Guidance literature:: In methanol; at -15 ℃; for 3h;
DOI:10.1021/jo00036a013

Reference yield:

: 100-65-2
N-Phenylhydroxylamine

: 140176-85-8,140385-01-9
(R)-(-)-2-phenyl-5-<(dimethylamino)methyl>isoxazolidin-3-one

Guidance literature:: Multi-step reaction with 7 steps

1: diethyl ether / 0.25 h

2: 48 percent / aq. sodium bicarbonate / diethyl ether / Ambient temperature

3: 61 percent / NaBH₄, LiCl / tetrahydrofuran; methanol / 0.17 h

4: pyridine / CH₂Cl₂

5: potassium phosphate buffer, pH 7 / lipase PS / acetone / Ambient temperature

6: 87 percent / potassium phosphate buffer, pH 7 / porcine pancreatic lipase / acetone / 5 h

With pyridine; sodium tetrahydroborate; potassium phosphate buffer; sodium hydrogencarbonate; lithium chloride; porcine pancreatic lipase; Lipase PS; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; acetone;
DOI:10.1021/jo00036a013

Reference yield:

: 140176-83-6
benzyl (+/-)-2-phenyl-3-oxo-5-isoxazolidinecarboxylate

: 140176-85-8,140385-01-9
(R)-(-)-2-phenyl-5-<(dimethylamino)methyl>isoxazolidin-3-one

Guidance literature:: Multi-step reaction with 5 steps

1: 61 percent / NaBH₄, LiCl / tetrahydrofuran; methanol / 0.17 h

2: pyridine / CH₂Cl₂

3: potassium phosphate buffer, pH 7 / lipase PS / acetone / Ambient temperature

4: 87 percent / potassium phosphate buffer, pH 7 / porcine pancreatic lipase / acetone / 5 h

With pyridine; sodium tetrahydroborate; potassium phosphate buffer; lithium chloride; porcine pancreatic lipase; Lipase PS; In tetrahydrofuran; methanol; dichloromethane; acetone;
DOI:10.1021/jo00036a013