2,2-dimethyl-N-(quinolin-8-yl)-3-(4-(trifluoromethyl)phenyl)propanamide

Base Information

Chemical Name:2,2-dimethyl-N-(quinolin-8-yl)-3-(4-(trifluoromethyl)phenyl)propanamide
CAS No.:1613145-79-1
Molecular Formula:C₂₁H₁₉F₃N₂O
Molecular Weight:372.39
Hs Code.:

Synonyms:2,2-dimethyl-N-(quinolin-8-yl)-3-(4-(trifluoromethyl)phenyl)propanamide

Suppliers and Price of 2,2-dimethyl-N-(quinolin-8-yl)-3-(4-(trifluoromethyl)phenyl)propanamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2,2-dimethyl-N-(quinolin-8-yl)-3-(4-(trifluoromethyl)phenyl)propanamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2,2-dimethyl-N-(quinolin-8-yl)-3-(4-(trifluoromethyl)phenyl)propanamide

There total 5 articles about 2,2-dimethyl-N-(quinolin-8-yl)-3-(4-(trifluoromethyl)phenyl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 578-66-5
8-amino quinoline

: 1439896-97-5
2,2-dimethyl-3-[4-(trifluoromethyl)phenyl]propanoic acid

: 1613145-79-1
2,2-dimethyl-N-(quinolin-8-yl)-3-(4-(trifluoromethyl)phenyl)propanamide

Guidance literature:: 2,2-dimethyl-3-[4-(trifluoromethyl)phenyl]propanoic acid; With oxalyl dichloride; In dichloromethane; N,N-dimethyl-formamide; at 0 - 20 ℃; Inert atmosphere;

8-amino quinoline; With triethylamine; In dichloromethane; N,N-dimethyl-formamide; at 0 - 20 ℃; for 6h; Inert atmosphere;
DOI:10.1002/chem.201603370

Reference yield:

: 170891-76-6
α,α,α-trimethyl-N-(quinolin-8-yl)acetamide

: 455-13-0
4-Iodobenzotrifluoride

: 1613145-79-1
2,2-dimethyl-N-(quinolin-8-yl)-3-(4-(trifluoromethyl)phenyl)propanamide

Guidance literature:: With triisobutylphosphane; C₂₆H₄₁N₂NiOP; In benzene-d6; at 70 ℃;
DOI:10.1021/acs.organomet.1c00265

Reference yield:

: 402-49-3
4-bromomethyltrifluoromethylbenzene

: 1613145-79-1
2,2-dimethyl-N-(quinolin-8-yl)-3-(4-(trifluoromethyl)phenyl)propanamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

1.2: 16 h / -78 - 25 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 - 25 °C / Inert atmosphere

2.2: 12 h / -78 - 25 °C / Inert atmosphere

With n-butyllithium; lithium diisopropyl amide; In tetrahydrofuran; hexane;
DOI:10.1002/anie.201311105