Trichloro-acetic acid (1S,2S)-2,4,4-trimethyl-3-oxo-1-phenyl-pentyl ester

Base Information

Chemical Name:Trichloro-acetic acid (1S,2S)-2,4,4-trimethyl-3-oxo-1-phenyl-pentyl ester
CAS No.:72658-18-5
Molecular Formula:C₁₆H₁₉Cl₃O₃
Molecular Weight:365.684
Hs Code.:

Synonyms:Trichloro-acetic acid (1S,2S)-2,4,4-trimethyl-3-oxo-1-phenyl-pentyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Trichloro-acetic acid (1S,2S)-2,4,4-trimethyl-3-oxo-1-phenyl-pentyl ester

Chemical Property:

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Technology Process of Trichloro-acetic acid (1S,2S)-2,4,4-trimethyl-3-oxo-1-phenyl-pentyl ester

There total 3 articles about Trichloro-acetic acid (1S,2S)-2,4,4-trimethyl-3-oxo-1-phenyl-pentyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 36677-29-9,87280-57-7,36677-30-2,95546-31-9,102285-82-5,110012-44-7,110012-45-8
(4SR,5SR)-5-hydroxy-5-phenyl-2,2,4-trimethyl-3-pentanone

: 76-02-8
trifluoroacetyl chloride

: 72658-18-5
Trichloro-acetic acid (1S,2S)-2,4,4-trimethyl-3-oxo-1-phenyl-pentyl ester

Guidance literature:: With pyridine; at 25 ℃; for 18h;
DOI:10.1021/jo01294a030

Reference yield:

: 3970-62-5
2,2-dimethyl-3-pentanol

: 72658-18-5
Trichloro-acetic acid (1S,2S)-2,4,4-trimethyl-3-oxo-1-phenyl-pentyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 89 percent / pyridinium chlorochromate / CH₂Cl₂ / 1.5 h

2: 1) lithium diisopropylamide / 1) THF, hexane, -70 deg C, 30 min; 2) -70 deg C, 10 min

3: 98 percent / pyridine / 18 h / 25 °C

With pyridine; pyridinium chlorochromate; lithium diisopropyl amide; In dichloromethane;
DOI:10.1021/jo01294a030

Reference yield:

: 564-04-5
2,2-dimethyl-3-pentanone

: 72658-18-5
Trichloro-acetic acid (1S,2S)-2,4,4-trimethyl-3-oxo-1-phenyl-pentyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1) lithium diisopropylamide / 1) THF, hexane, -70 deg C, 30 min; 2) -70 deg C, 10 min

2: 98 percent / pyridine / 18 h / 25 °C

With pyridine; lithium diisopropyl amide;
DOI:10.1021/jo01294a030