(E)-tert-butyl (4-(4-((1-(3-aminopropyl)-1H-1,2,3-triazol-4-yl)methoxy)styryl)phenyl)methylcarbamate

Base Information

Chemical Name:(E)-tert-butyl (4-(4-((1-(3-aminopropyl)-1H-1,2,3-triazol-4-yl)methoxy)styryl)phenyl)methylcarbamate
CAS No.:1422568-50-0
Molecular Formula:C₂₆H₃₃N₅O₃
Molecular Weight:463.58
Hs Code.:

Synonyms:(E)-tert-butyl (4-(4-((1-(3-aminopropyl)-1H-1,2,3-triazol-4-yl)methoxy)styryl)phenyl)methylcarbamate

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Chemical Property of (E)-tert-butyl (4-(4-((1-(3-aminopropyl)-1H-1,2,3-triazol-4-yl)methoxy)styryl)phenyl)methylcarbamate

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Technology Process of (E)-tert-butyl (4-(4-((1-(3-aminopropyl)-1H-1,2,3-triazol-4-yl)methoxy)styryl)phenyl)methylcarbamate

There total 5 articles about (E)-tert-butyl (4-(4-((1-(3-aminopropyl)-1H-1,2,3-triazol-4-yl)methoxy)styryl)phenyl)methylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 88192-19-2
3-azidopropylamine

: 1422568-49-7
(E)-tert-butyl methyl(4-(4-(prop-2-yn-1-yloxy)styryl)phenyl)carbamate

: 1422568-50-0
(E)-tert-butyl (4-(4-((1-(3-aminopropyl)-1H-1,2,3-triazol-4-yl)methoxy)styryl)phenyl)methylcarbamate

Guidance literature:: With copper(l) iodide; N-ethyl-N,N-diisopropylamine; In dichloromethane; for 15h; Inert atmosphere;
DOI:10.1021/jm301435z

Reference yield:

: 42822-57-1
diethyl (4-aminophenyl)phosphonate

: 1422568-50-0
(E)-tert-butyl (4-(4-((1-(3-aminopropyl)-1H-1,2,3-triazol-4-yl)methoxy)styryl)phenyl)methylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: water; tetrahydrofuran / 20 °C

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0 - 20 °C / Inert atmosphere

3.1: sodium hydride / N,N-dimethyl-formamide / 1 h / Inert atmosphere

3.2: 12 h / Inert atmosphere

4.1: N-ethyl-N,N-diisopropylamine; copper(l) iodide / dichloromethane / 15 h / Inert atmosphere

With copper(l) iodide; sodium hydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; mineral oil; 3.2: |Horner-Wadsworth-Emmons Olefination;
DOI:10.1021/jm301435z

Reference yield:

: tert-butyl (4-((diethoxyphosphoryl)methyl)phenyl)(methyl)carbamate

: 1422568-50-0
(E)-tert-butyl (4-(4-((1-(3-aminopropyl)-1H-1,2,3-triazol-4-yl)methoxy)styryl)phenyl)methylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 1 h / Inert atmosphere

1.2: 12 h / Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine; copper(l) iodide / dichloromethane / 15 h / Inert atmosphere

With copper(l) iodide; sodium hydride; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; 1.2: |Horner-Wadsworth-Emmons Olefination;
DOI:10.1021/jm301435z