(E)-tri-tert-butyl 2,2′,2″-(10-(2-((3-(4-((4-(4-((tert-butoxycarbonyl)(methyl)amino)styryl)phenoxy)methyl)-1H-1,2,3-triazol-1-yl)propyl)amino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate

Base Information

Chemical Name:(E)-tri-tert-butyl 2,2′,2″-(10-(2-((3-(4-((4-(4-((tert-butoxycarbonyl)(methyl)amino)styryl)phenoxy)methyl)-1H-1,2,3-triazol-1-yl)propyl)amino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate
CAS No.:1422568-51-1
Molecular Formula:C₅₄H₈₃N₉O₁₀
Molecular Weight:1018.31
Hs Code.:

(E)-tri-tert-butyl 2,2′,2″-(10-(2-((3-(4-((4-(4-((tert-butoxycarbonyl)(methyl)amino)styryl)phenoxy)methyl)-1H-1,2,3-triazol-1-yl)propyl)amino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate

Synonyms:(E)-tri-tert-butyl 2,2′,2″-(10-(2-((3-(4-((4-(4-((tert-butoxycarbonyl)(methyl)amino)styryl)phenoxy)methyl)-1H-1,2,3-triazol-1-yl)propyl)amino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate

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Chemical Property of (E)-tri-tert-butyl 2,2′,2″-(10-(2-((3-(4-((4-(4-((tert-butoxycarbonyl)(methyl)amino)styryl)phenoxy)methyl)-1H-1,2,3-triazol-1-yl)propyl)amino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate

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Technology Process of (E)-tri-tert-butyl 2,2′,2″-(10-(2-((3-(4-((4-(4-((tert-butoxycarbonyl)(methyl)amino)styryl)phenoxy)methyl)-1H-1,2,3-triazol-1-yl)propyl)amino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate

There total 6 articles about (E)-tri-tert-butyl 2,2′,2″-(10-(2-((3-(4-((4-(4-((tert-butoxycarbonyl)(methyl)amino)styryl)phenoxy)methyl)-1H-1,2,3-triazol-1-yl)propyl)amino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1422568-50-0
(E)-tert-butyl (4-(4-((1-(3-aminopropyl)-1H-1,2,3-triazol-4-yl)methoxy)styryl)phenyl)methylcarbamate

: 137076-54-1
1,4,7-tris(tert-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane-10-acetic acid

: 1422568-51-1
(E)-tri-tert-butyl 2,2′,2″-(10-(2-((3-(4-((4-(4-((tert-butoxycarbonyl)(methyl)amino)styryl)phenoxy)methyl)-1H-1,2,3-triazol-1-yl)propyl)amino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate

Guidance literature:: With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 12h;
DOI:10.1021/jm301435z

Reference yield:

: 42822-57-1
diethyl (4-aminophenyl)phosphonate

: 1422568-51-1
(E)-tri-tert-butyl 2,2′,2″-(10-(2-((3-(4-((4-(4-((tert-butoxycarbonyl)(methyl)amino)styryl)phenoxy)methyl)-1H-1,2,3-triazol-1-yl)propyl)amino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: water; tetrahydrofuran / 20 °C

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0 - 20 °C / Inert atmosphere

3.1: sodium hydride / N,N-dimethyl-formamide / 1 h / Inert atmosphere

3.2: 12 h / Inert atmosphere

4.1: N-ethyl-N,N-diisopropylamine; copper(l) iodide / dichloromethane / 15 h / Inert atmosphere

5.1: benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 12 h / 20 °C

With copper(l) iodide; sodium hydride; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; mineral oil; 3.2: |Horner-Wadsworth-Emmons Olefination;
DOI:10.1021/jm301435z

Reference yield:

: tert-butyl (4-((diethoxyphosphoryl)methyl)phenyl)(methyl)carbamate

: 1422568-51-1
(E)-tri-tert-butyl 2,2′,2″-(10-(2-((3-(4-((4-(4-((tert-butoxycarbonyl)(methyl)amino)styryl)phenoxy)methyl)-1H-1,2,3-triazol-1-yl)propyl)amino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 1 h / Inert atmosphere

1.2: 12 h / Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine; copper(l) iodide / dichloromethane / 15 h / Inert atmosphere

3.1: benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 12 h / 20 °C

With copper(l) iodide; sodium hydride; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; 1.2: |Horner-Wadsworth-Emmons Olefination;
DOI:10.1021/jm301435z